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瑞芬太尼与芬太尼全麻诱导的对比观察

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摘要 目的观察等剂量的瑞芬太尼或芬太尼复合异丙酚全麻诱导气管内插管对血压、心率的影响和不良反应。方法160例择期手术全麻病人,分8组每组20例,全麻诱导用咪唑安定0·08mg/kg、异丙酚1·5mg/kg、瑞芬太尼(RF)或芬太尼(F)、阿曲库铵。瑞芬太尼或芬太尼的剂量分别是Ⅰ组1μg/kg、Ⅱ组2μg/kg、Ⅲ组31μg/kg、Ⅳ组4μg/kg,记录麻醉诱导前(T0)、窥喉前(T1)、导管插入即刻(T2)及气管插管后1min(T3)、3min(T4)、5min(T5)、10min(T6)的血压(SBP、DBP)和心率(HR)变化,观察有无胸腹肌肉僵硬等不良反应。结果①与基础值相比,麻醉诱导后各组HR、SBP、DBP均明显下降(P<0·01);从导管插入即刻起,血压、心率开始回升,除RFⅢ组、RFⅣ组的SBP在气管插管后1、3min仍较低(P<0·05),以及FⅠ组的SBP在气管插管后1min较高(P<0·05)外,其余均恢复麻醉前水平(P>0·05)。②相同剂量的RF、F组间比较:RF对SBP、DBP的抑制强于F(P<0·05)。结论相同剂量的瑞芬太尼比芬太尼能更有效抑制气管插管所引起的心血管反应。
出处 《广西医学》 CAS 2006年第4期526-528,共3页 Guangxi Medical Journal
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参考文献2

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