摘要
对用于研究病毒唑作用机理的光敏探针进行了设计,并以四乙酰核糖化合物和3-溴-1,2,4-三唑-5-酰甲酯化合物为原料进行合成实验,得到光敏探针化合物5-叠氮基-1-(β-呋喃核糖基)-1,2,4-三唑-3-酰胺和3-叠氮基-1-(β-呋喃核糖基)-1,2,4-三唑-5-酰胺.采用IR,MS和1H NMR等技术对化合物的结构进行了表征,同时对探针分子的设计和结构判定进行了探讨.
The photolabeling probes for the study of antiviral mechanism of ribavirin were designed, and the synthesis experiments were carried out by using 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose and methyl 3-bromo- 1,2,4-triazole-5-carboxylate as the raw materials. Two photolabeling probes for the study of antiviral mechanism of ribavirin, 5-azido-l-（β-ribofuranosyl）-I ,2,4-triazole-3-carboxamide and 3-azido-1-（β-ribofuranosyl）- 1,2,4-triazole-5-carboxamide were synthesized, and characterized by IR, MS and ^1H NMR, etc.. The design of the photolabeling probes and their structures were discussed.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2006年第6期1062-1065,共4页
Chemical Journal of Chinese Universities
