摘要
目的：探讨难治性抑郁症的相关危险因素，为临床防治及护理提供依据。方法：将190例难治性抑郁症标准的抑郁症与同期的非难治性抑郁症进行1：1配比病例对照研究，应用条件Logistic回归分析方法处理数据。结果：多因素条件Logistic回归分析表明难治性抑郁症的危险因素是：双相情感障碍（OR：3．689，95％CI：1．816～7．332），神经质（OR：4．461，95％CI：1．791～10．890），伴有精神病性症状（OR：4．362，95％CI：2．184～8．411），情感疾病家族史（OR=0．368，95％CI：0．020～0．917），1年内未及时治疗（OR：0．409，95％CI：0．208～0．830）。结论：具有双相情感障碍、神经质、伴有精神病性症状、情感疾病家族史、1年内未及时治疗与加强护理是难治性抑郁症的重要危险因素。
Objective ：To explore the risk factors of refractory depression and to provide the clinician with some indications for prevention and treatment. Methods：A 1 ： lmatched case - controll study was carried out in including 190 cases and the same number of controls. A conditional logistic regression model was used for statistical analysis. Results： Multivariate conditional logistic regression analysis showed that refractory depression was significantly related with five risk factors including bipolar disorder （ OR = 3. 689,95% CI ： 1.816 - 7. 323 ） , neuroticism （ OR = 4.461,95% CI： 1. 792 - 10. 891 ） , with psychotic symptoms （ OR = 4. 363,95% C1：2.185 - 8. 412 ） ,family history of mood disorder （OR = 0.369,95% C1：0.0121 - 0.918 ）, inadequate treatment within the first year （OR = 0. 410,95% C1：0. 209 - 0.831 ）. Conclusions. Bipolar disorder, neuroticism, with psychotic symptoms, family history and inadequate treatment and nursing within first one year were main risk factors for refractory depression.
出处
《中国民康医学》
2006年第11期445-446,共2页
Medical Journal of Chinese People’s Health
关键词
难治性抑郁症
危险因素
护理
Refractory depression
Risk factors
Nursing
