摘要
目的 探讨栓塞治疗在异基因造血干细胞移植（allo-HSCT）术后重度出血性膀胱炎（HC）中的应用价值。方法 6例接受allo-HSCT的患者在移植后24～80 d发生重度（Ⅲ～Ⅳ度）HC，经保守治疗无效，在数字减影血管造影（DSA）下行选择性双侧髂内动脉脏支栓塞术治疗。结果 6例患者共行8次栓塞治疗，4例治愈，1例好转，1例无效，有效率达83％。4例治愈的患者肉眼血尿消失时间为栓塞术后7～10 d，镜下血尿消失时间为栓塞术后20～30 d。6例患者均未出现严重并发症。结论 应用选择性双侧髂内动脉栓塞治疗重度HC是一种安全有效的措施，是治疗allo-HSCT后难治性、迁延不愈的重度HC的一种新的治疗手段。
Objective To investigate the therapeutic value of embolization in severe hemorrhagic cystitis （HC） following allogeneic stem cell transplantation. Methods Six patients undergoing allogeneic stem cell transplantation developed severe HC with a median onset time of 33 days after transplantation. All these patients had been resistant to conservative managements and received the treatment of selective embolization of bilateral internal iliac arteries. Results Eight times of embolizations were performed for 6 patients. The HC was cured in 4 patients and the HC improved in 1 patient, yielding a response rate of 83%. One patient didn＇t respond to this measure. For the patients with response, macroscopic hematuria disappeared 7 to 10 days after the treatments and microscopic hematuria vanished 20 to 30 days after the intervention therapy. Both procedures were tolerated well and no severe adverse effects were observed. Conclusions Selective embolization of internal iliac arteries seems to be a safe and effective treatment for severe HC. This measure can be proposed for patients undergoing refractory and persistent severe HC.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2006年第6期345-347,共3页
Chinese Journal of Organ Transplantation
基金
江苏省卫生厅科研基金资助项目(H200516)
关键词
造血干细胞移植
膀胱炎
重度
放射学
介入性
Hematopoietic stem cell transplantation
Cystitis, severe
Radiology, interventional
