摘要
采用反相高效液相色谱法分离和测定1,1＇-联-2-萘酚和2-萘酚.在选定的色谱条件下,1,1＇-联-2-萘酚与2-萘酚等杂质之间具有较好的分离效果.该方法具有操作简单、快速、准确度和精密度较好,对同一1,1＇-联-2-萘酚和2-萘酚试样分别进行五次平行独立测定的标准偏差分别为0.60和0.46;相对标准偏差分别为0.61%和0.47%;加入法回收率分别为98.42%～102.8%和98.21%～102.0%.
The separation and measurement of 2,2＇-Dihydroxy-1, 1＇-binaphthyl and 2-Naphthol by Reversed-phase HPLC have been studied. Under the selected chromatographic operation conditions, the 2,2＇-Dihydroxy-1, 1＇-binaphthyl, 2-Naphthol and other impurities could be separated efficiently. The method is simple, quick and accurate. Five parallel tests have been carried out for the 2,2＇-Dihydroxy-1, 1＇-binaphthyl and 2-Naphthol sample and gave a mean value of 99.13 % and 98. 76% with a standard deviation of 0.60 and 0.46, and a coefficient of variation of 0.61% and 0.47%. The recovery of the method is 98.42%-102.8% and 98.21%~102.0%, respectively.
出处
《浙江工业大学学报》
CAS
2006年第3期286-289,共4页
Journal of Zhejiang University of Technology
关键词
1
1'-联-2-萘酚
2-萘酚
高效液相色谱
2,2＇-dihydroxy-1,1＇-binaphthyl
2-naphthol
high-performance liquid chromatography
