摘要
目的:探讨阻塞性呼吸暂停综合征(OSAHS)与颈动脉内膜中层厚度(IMT)之间的关系。方法:对应用多导睡眠监测仪监测诊断的96例OSAHS患者进行彩色多普勒超声颈动脉IMT检测,并将OSAHS患者分成轻度组(32例)、中度组(34例)、重度组(30例),分析颈动脉IMT与睡眠呼吸紊乱指数(AHI)、平均血氧饱和度(SaO2)、夜间最低SaO2、SaO2<90%时间及氧减指数的相关性。结果:轻、中、重度3组间颈动脉IMT的差异有统计学意义(P<0.05),且随着OSAHS程度加重颈动脉IMT有增加趋势。AHI(r=0.509,P<0.001)、SaO2<90%时间(r=0.351,P<0.01)、氧减指数(r=0.472,P<0.001)与颈动脉IMT呈正相关,夜间最低SaO2(r=-0.391,P<0.01)与IMT呈负相关。结论:OSAHS与颈动脉IMT相关,随着阻塞性呼吸不足持续时间的延长和SaO2的下降,颈动脉IMT增厚的可能性增加。
Objective To study the relationship between the carotid intima-media thickness（IMT） and obstructive sleep apnea hypopnea syndrome （OSAHS） , Methods Ninety six patients with OSAHS were diagnosed using polysomnography （PSG） and then divided into mild （ n=32）, moderate （ n=34）. and severe OSAHS group （ n=30）. Their carotid IMT was measured by color Doppler ultrasonography and their apnen-hypopnea index （AHI）, oxygen desaturation index, sleep duration with SaO2〈90%, the lowest SaO2 and mean SaO2 during overnight sleep were detected by PSG. The correlation between the carotid IMT and the data from PSG was analysed. Results There was a significant difference among the carotid IMT in the three groups （ P〈0.05） and a tendency for the carotid IMT to increase with the aggravation of OSAHS. AHI（ r=0.509, P〈0.001）, sleep duration with SaO2〈90% （ r=0.351, P〈0.01）, and oxygen desaturation index （ r=0. 472, P〈0.001 ） had a positive relation with the carotid IMT while the lowest SaO2 （ r =-0.391, P〈0.01 ） during overnight sleep had a negative relation with the carotid IMT, Conclusion There was a significant correlation between the carotid IMT and OSAHS. The carotid IMT could probably increase due to the prolonged duration of obstructive hypopnea and the decreased arterial oxygen saturation.
出处
《实用医学杂志》
CAS
2006年第11期1243-1245,共3页
The Journal of Practical Medicine
基金
广东省医学科研基金资助项目(编号:A2005010)
关键词
睡眠呼吸暂停
阻塞性
颈动脉
内膜中层厚度
Sleep apnea, obstructive Carotid arteries Intima-media thickness
