摘要
在二氯乙烷／水两相溶剂体系中，用奎宁为拆分试剂，经由生成非对映异构的盐，成功地拆分了（±）顺、反式混合菊酸１．奎宁与（±）－１的摩尔比为０．６５∶１．当（±）－１的顺／反比为２６∶７４或１７∶８３时，均能用此拆分方法得到满意的拆分结果．拆分产物（＋）－反式－１的顺／反比为８∶９２，旋光纯度为９２％．
Mixture of (±)-cis-and trans-chrysanthemic acid 1 wassuccessfully resolved into (+)-trans-1 and (-)-trans-1 viathe diastereomeric salts by using quinine as resolution reagentin two-phase solvent system, 1, 2-dichloroethane/water. The molarratio, 1: 0. 65,of mixture of (±)-1 and quinine was used inthis resolution method. When the ets/trans ratio of (±)-1 isequal to 17: 83 or 26: 74,the resolution product (+)-trans-1 with 92% optical purity and ets/trans ratio, 8: 92,can be smoothly obtained.
出处
《南开大学学报（自然科学版）》
CAS
CSCD
1996年第1期95-98,102,共5页
Acta Scientiarum Naturalium Universitatis Nankaiensis
基金
天津市自然科学基金
