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CpG ODN2006对乙型肝炎疫苗免疫BALB/c小鼠抗体产生的影响 被引量：2

Influence of CpG ODN2006 on Antibody Production in BALB/c Mice Immunized with Hepatitis B Vaccine
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摘要 目的探讨合成含CpG基序的寡脱氧核苷酸(CpGODN2006)对乙型肝炎疫苗增强小鼠特异性抗体产生的效应。方法采用BALB/c小鼠,经后腿胫骨前肌注免疫2次,ELISA法检测血清中抗HBsIgG效价。结果疫苗+CpG组较疫苗组和空白对照组的抗HBsIgG效价明显增高,且维持时间长。结论CpGODN2006对小鼠抗HBsIgG的产生具有明显的增强作用。 Objective To explore the influence of synthetic CpG ODN2006 on the production of specific antibody in mice immunized with hepatitis B(HB) vaccine.Methods Divide BALB/c mice into test and control groups and immunize twice with CpG ODN2006+HB vaccine and HB vaccine respectively.Separate murine sera for determination of anti-HBs IgG titers by ELISA.Results Compared with those in control group,the anti-HBs IgG titer of mice in test group was significantly high and persistent.Conclusion CpG ODN2006 enhanced the production of anti-HBs IgG in mice.
作者 郑源强 石艳春 杨贵贞
机构地区 内蒙古医学院分子生物学研究中心 吉林大学医学部基础医学院免疫学教研室
出处 《中国生物制品学杂志》 CAS CSCD 2006年第3期223-224,共2页 Chinese Journal of Biologicals
基金 内蒙古自然科学基金项目资助(200508010905).
关键词 CPG ODN 乙型肝炎疫苗 抗体 佐剂 CpG ODN Hepatitis B vaccine Antibody Adjuvant
分类号 R57 [医药卫生—消化系统] R593.1 [医药卫生—内科学]
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参考文献7

  • 1Chu RS,Targoni OS,Krieg AM,et al.CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.J Exp Med,1997,186:1623-1631.
  • 2石艳春,杨贵贞.CpG ODN对rHBsAg免疫小鼠Th1/Th2型免疫应答的影响[J].中国免疫学杂志,2005,21(5):329-331. 被引量：8
  • 3Krieg AM.CpG motifsin bacterial DNA andtheirimmune effects.Annual Rev Immunol,2002,20:709-760.
  • 4石艳春,杨贵贞.CpG ODN增强乙型肝炎表面抗原免疫小鼠的抗体产生[J].中国免疫学杂志,2003,19(1):9-11. 被引量：11
  • 5Hartmann G,Weeratna RD,Ballas ZK,et al.Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo.J Immunology,2000,164:1617-1624.
  • 6Liang H,Nishiok Y,Reich CF,et al.Activation of human B cells by phosphoriothioate oligodeoxynucleotides.J Clin Invest,1996,98(5):1119-1129.
  • 7Krieg AM,Wagner H.Causing a commotion in the blood:Immunotherapy progress from bacterial to bacterial DNA.Immunol Today,2000,21 (10):521-526.

二级参考文献19

  • 1[1]Krieg A M. CpG motifs in bacterial DNA and their immune effects[J].Annual Rev Immunol,2002;20:709.
  • 2[2]Klinman DM, Conover J, Coban C. Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection[J] .Infection and Immunity, 1999;67(11):5658.
  • 3[3]Krieg AM, Davis HL. Enhancing vaccines with immune stimulatory CpG DNA[J].Current Opinion in Molecular Theraputics,2001;3(1) :15.
  • 4[4]Krieg AM, MatsonS, Waldschmidt T J et al. CpG motifs in bacterial DNA trigger direct B-cell activation[J].Natuwe, 1995;374(6522):546.
  • 5[6]Weeratna R D, McCluakie M J, Xu Y et al.CpG DNA induces stronger immune responses with less toxicity than other adjuvants[J] .Vaccine,2000; 18(1): 1755.
  • 6[7]Krieg A M, Wagner H. Causing a commotion in the blood:immunotherapy progress from bacterial to bacterial DNA[J] .Immunology Today,2000; 21 (10) :521.
  • 7[8]Liang H, Nishiok Y, Reich C F et al. Activation of human B cells by phospho riothioate oligodeoxynucleotides[J]. J Clin Invest, 1996;98(5):1119.
  • 8Krieg A M.CpG motifs in bacterial DNA and their immune effects [J].Annual Rev Immunol,2002;20:709-760.
  • 9Krieg A M,Wagner H.Causing a commotion in the blood:immune therapy progresses from bacteria to bacterial DNA [J].Immunology Today,2000;21(10):521-525.
  • 10Abbus A K,Lichtman A H.Cellular and molecular immunology [M].5th edition.Peking:Peking University Medical Press,2004:15.

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中国生物制品学杂志
2006年 第3期

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