摘要
目的观察蒿芩清胆汤治疗系统性红斑狼疮(SLE)活动期的疗效和安全性。方法选取SLE患者120例,随机分为两组,治疗组用蒿芩清胆汤和泼尼松,对照组用泼尼松和环磷酰胺,疗程3个月。观察治疗前后SLE活动指数(SLEDAI)及各项免疫指标,血尿常规、肝肾功能及其他不良反应发生情况。结果治疗组和对照组总有效率分别为81·67%(49/60例)、76·67%(46/60例),两组比较差异无显著性。两组在改善SLEDAI、血沉(ESR)、C3、24h尿蛋白定量、抗dsDNA抗体方面均取得满意效果,治疗组未发现明显不良反应。结论蒿芩清胆汤治疗SLE活动期疗效显著,安全性好。
Objective To observe the therapeutic efficacy and safety of Haoqin Qingdan Decoction （HQD） in treating active stage of systemic lupus erythematosus （SLE）. Methods One hundred and twenty patients with SLE were randomly assigned into two groups, the treated group receiving HQD and prednisone, and the control group receiving prednisone and cyclophosphamide （CTX）, both were treated for 3 months. SLE disease activity index（SLEDAI）, various immunological indexes, blood and urine routine, hepatic and renal function, as well as the other adverse reaction of the treatment were observed. Results The total effective rate in the treated group was 81.67 % （49/60）, while 76.67 % （46/60） in the control group, showing insignificant difference between the two groups. SLEDAI, erythrocyte sedimentation rate （ESR）, complement 3 （C3）, 24-hr urinary protein excretion and anti-double strain deoxyribonucleic acid （dsDNA） antibody were improved in the treated group, and no obvious adverse reaction was shown. Conclusion HQD is obviously more effective in treating active stage of SLE with high safety.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2006年第5期448-450,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
系统性红斑狼疮
蒿芩清胆汤
systemic lupus erythematosus
Haoqin Qingdan Decoction
