摘要
目的:探讨抗心磷脂抗体(ACA)及抗2β-糖蛋白Ⅰ(2β-GPⅠ)抗体与系统性红斑狼疮(SLE)患者心脏瓣膜病变的关系。方法:用超声心动图(UCG)分析60例SLE患者心脏受累情况,同时应用酶联吸附试验(ELISA)对32例经超声心动图(UCG)确诊合并心脏瓣膜病变的SLE患者血清中的ACA及抗2β-糖蛋白Ⅰ抗体进行检测,并以28例无心脏瓣膜病变的SLE患者及20例正常人血清为对照。结果:合并心脏瓣膜病变的SLE患者血清ACA及抗2β-GPⅠ抗体的阳性率分别为(68.75%和59.37%),较无心脏瓣膜病变的SLE患者组(32.14%和7.14%)显著增高(P<0.05和P<0.01)。结论:抗2β-GPⅠ抗体不仅与SLE心脏瓣膜病变关系密切而且特异性比ACA高,可能成为SLE心脏瓣膜病变的重要指标。
Objective： To study the relationship between heart valvular disease and anticardiolipin antibody （ACA） and anti-β2- glycoprotein Ⅰ antibody （anti-β2-GP Ⅰ ） in patients with systemic lupus erythematosus （SLE）. Methods： Echocardiography（UCG） for cardiac involvement were analyzed in 60 SLE patients. The ACA and anti-β2-GP Ⅰ antibody were detected in 32 SLE patients with heart valvular disease by the enzyme linked immunosorbend assay （ELISA）,and 28 cases without heart valvular disease. Results： Elevated levels of ACA and anti-β2-GP Ⅰ were found in patients with heart valvular disease. The positive rate of ACA arid anti-β2-GP Ⅰ was 68.75% and 59.37%, respectively. Conclusion： These results suggest that anti-β2-GP Ⅰ is not only closely associated with heart valvular disease of patients with SLE but also strongly specified than AC.A, and may be an important marker for heart valvular disease in patients with SLE.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2006年第6期438-440,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
南京市卫生局医学科技发展课题资助项目(YKKO459)
关键词
红斑狼疮
系统性
心脏瓣膜病
抗心磷脂抗体
抗β2-糖蛋白Ⅰ抗体
systemic lupus eythematosus
heart valvular disease
anticardiolipin antibody
anti-β2-glycoprotein Ⅰ antibody
