摘要
目的比较不同胰岛素给药方法对糖尿病酮症酸中毒的治疗差异。方法将住院治疗的44例糖尿病酮症(DK)及酮症酸中毒(DKA)患者随机分为两组,连续皮下胰岛素注射治疗组(CSII)与常规小剂量胰岛素0.1 IU/(kg.h)静脉滴注组(对照组),每组各22例,两组年龄、血糖和体重指数(BMI)相比无显著性差异,观察血糖及尿酮体变化。结果①两组患者的血糖在使用胰岛素泵和小剂量胰岛素静脉滴注治疗后均明显下降,无显著差异(t=0.832,P>0.05)。②胰岛素泵治疗组患者治疗后尿酮体转阴时间为(17.6±7.4)h,对照组为(46.3±11.2)h;两组差异具有显著性(t=17.729,P<0.01)。结论胰岛素泵模拟胰岛素的生理分泌模式,能更快、更有效地纠正代谢紊乱,控制高血糖,可以取得比对照组更加满意的疗效。
Objective To compare the efficacy of two different ways of insulin delivery on diabetic ketoacidosis（DKA）. Methods Forty-four patients with DK and DKA were randomly divided into two groups,22 cases in each： continous subcutaneous insulin infusion treated group（CSII） and low dose insulin 0.1 IU/（kg·h） intravenous infusion treated group（control group）. Patients in two groups were matched in age, blood glucose and BMI. Blood glucose and urinary ketone bodies were observed. Results ①The level of blood glucose control were both remarkably induced after using two different ways of insulin delivery. There was no significantly difference in two groups（ t = 0. 832, P 〉 0.05）. ②It took （ 17.6 ± 7.4） h in CSI I group and（46.3 ± 11.2） h in control group to reverse the urinary ketosis which were significant difference（ t = 17. 729, P〈 0.01）. Conclusion Insulin pump simulated pattern of insulin secretion is effective in treating ketoacidosis and hyperglycemia. It can make a better effect than control group.
出处
《山西医科大学学报》
CAS
2006年第3期278-279,共2页
Journal of Shanxi Medical University
