摘要
目的探讨炎症因子CRP、TNF-α与冠脉病变的关系及意义。方法收集114例拟行选择性冠状动脉造影(CAG)的患者,其中正常对照组34例,冠心病组80例。所有患者均用Backman全自动生化分析仪测定空腹血糖、血脂等指标,用放射免役法测定肿瘤坏死因子α(TNF-α)。采用散射光比浊法测定C反应蛋白(CRP)。入院后2-5 d内行CAG,按照Califf介绍的危险分数(jeopardy score)评价选择性冠脉造影冠脉病变情况。结果冠心病组CRP、TNF-α水平均较正常对照组明显升高;相关分析显示,冠心病患者TNF-α、CRP与冠脉评分呈正相关。结论冠心病患者CRP、TNF-α等炎症因子的水平明显增高,随着冠脉病变加重,CRP、TNF-α也逐渐增高,炎症反应可能参与了冠心病的发生、发展。
Objective To explore the relationship between the inflammation factors and the coronary lesions in coronary heart disease （CHD） patients. Methods One hundred and fourteen patients were included in the study： normal control group（ n = 34） and coronary heart disease group（ n = 80）. The levels of C-reactive protein（CRP）, tumor necrosis factor a （TNF-α） were analyzed respectively. All the patients also had coronary angiography and the extent of coronary artery injury was evaluated. Results The levels of TNF-α .CRP in CHD group were significantly higher than those of normal control group（ P 〈 0.01 ）. Correlation analysis showed that the levels of jeopardy scores are positively correlated with those of CRP and TNF-α in CHD patients. Conclusion Inflammation reaction occurs in all CHD patients,the levels of TNF-α,CRP in CHD patients are high. Jeopardy scores are positively correlated with CRP,TNF-α.
出处
《山西医科大学学报》
CAS
2006年第3期272-274,共3页
Journal of Shanxi Medical University
