摘要
目的研究异丙酚在胃镜检查中的镇静效果及安全性。方法胃镜检查患者698例为镇静剂组,给予异丙酚镇静;710例为对照组,不使用任何镇静剂。比较两组胃镜检查中患者的反应及感受;胃镜检查时间;清醒时间;观察检查前、中、后患者血压、心率和血氧饱和度的改变。结果镇静剂组99.1%患者无不适,而对照组仅为26.3%(P<0.05);镇静剂组患者恶心呕吐、呃逆、呛咳、躁动、咽喉不适发生率分别为1.8%、1.0%、0.7%、0.2%和1.4%,明显低于对照组(相应为26.5%、3.7%、4.1%、5.1%和27.9%);镇静剂组胃镜操作时间为(3.8±2.3)min,短于对照组(5.3±3.6)min;镇静剂组患者清醒时间为(1.8±1.3)min,检查时出现血压下降,检查结束后恢复至检查前水平。结论胃镜检查时应用异丙酚镇静,是一种安全、有效的方法。
[Objective] To investigate the efficacy and safety of propofol in gastroscopy. [Methods] 698 patients in sedative group were treated with propofol alone, while 710 patients in control group were given no sedation, Procedure-related parameters, such as the recovery time, operative duration as well as the patient＇s discomfort, co-operation and tolerance to the procedure were prospectively assessed. Vital signs （heart rate, blood pressure, oxygen saturation） were eontinuously monitored in all patients. [Results] 99.1% patients in sedative group eompares with 26.3% patients in eontrol group had not told any discomfort during gastrostropie proeedures （P 〈0.05）. The ineidenee rate of nausea and vomiting, hiecough, eough, restless and guttural discomfort in sedative group were 1.8%, 1.0%, 0.7%, 0.2% and 1.4% respectively, lower than those in eontrol group aeeordingly. The operative duration in sedative group was significantly shorter than in eontrol group （3.8±2.3 min VS 5.3±3.6 rnin; P 〈0.05）. The recovery time in sedative group was （1.8±1.3） rain. The blood pressure deereased signifieant by using propofol （P 〈0.05） but recovered after the procedure. [Conclusion] Propofol is an alternative drug for sedation that makes gastroscopy be performed safely and effectively.
出处
《中国内镜杂志》
CSCD
北大核心
2006年第5期508-510,共3页
China Journal of Endoscopy
关键词
异丙酚
胃镜检查
镇静
propofol
gastroscopy
sedation
