摘要
通过对４４例病毒性肝炎患者Ｔ细胞亚群，ＮＫ细胞活性与ＬＡＫ细胞活性的观察，探讨了在慢性乙型肝炎病毒复制与非复制状态下的杀伤性细胞活性。结果表明：在乙肝病毒的高复制状态下，ＣＤ８＋细胞数增加，ＣＤ４＋／ＣＤ８＋比例显著下降；ＮＫ细胞活性与ＬＡＫ细胞活性也明显低下，且在ＨＢｅＡｇ与ＨＢＶＤＮＡ阳性组中，ＮＫ活性与ＬＡＫ活性的改变与ＨＢｅＡｇ的Ｐ／Ｎ值变化呈显著负相关，而ＮＫ活性与ＬＡＫ活性变化则呈正相关。此外，在慢迁肝患者中，ＣＤ８＋细胞也高于慢活肝，而ＮＫ活性和ＬＡＫ活性则低于慢活肝。提示：杀伤性免疫细胞在抗乙肝病毒感染过程中具有重要作用，并为临床采用免疫细胞进行抗病毒治疗提供了一定的依据。
In order to investigate the cytotoxicity of killer cells in replication and non-replication conditions of chronic HBV infection, we determined the percentage of blood T cell subsets,natural killer(NK)activity,and lymphokine-activated killer(LAK) activity in 44 patients with viral hepatitis. The results showed that in high viral replication group,the percentage of CD T cells was increased and the ratio of CD4/CD8, NK and LAK activity were significantly decreased.The NK activity and LAK activity were inversely correlated with P/N value of HBeAg in HBeAg and HBV DNA positive group, positive correlation was also found between NK and LAK activity in this group. In addition,we had also observed that in chronic persistent hepatitis,the percentage of CD T cells were higher than that of chronic active hepatitis and NK, LAK activity were lower than CAH.These results suggested that the cytotoxicity of the killer cells has an important role in immune responses against HBV infection.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1996年第1期43-47,共5页
Immunological Journal
关键词
乙型肝炎
免疫细胞功能
T细胞亚群
NK细胞
T cell subsets
Natural killer cell
Lymphokine-activated killer cells,Viral hepatitis
