转化生长因子β_1和VEGF在甲状腺癌组织中的表达及其与血管生成的关系被引量：4

Relationship of the expression of transforming growth factor,vascular endothelial growth factor with angiogenesis in thyroid cancer

原文传递

导出

摘要目的探讨转化生长因子(TGF)β1和血管内皮生长因子(VEGF)在甲状腺癌组织中的表达及其与肿瘤血管生成的关系。方法采用免疫组织化学方法,检测46例甲状腺癌组织中TGFβ1与VEGF表达及肿瘤微血管计数(MVC)。结果46例甲状腺癌组织中TGFβ1阳性表达率为63.04%(29/46),TGFβ1阳性表达者MVC值(26.18±4.05)显著大于阴性表达者(20.13±4.29),VEGF阳性表达者35例,阳性表达率为79.06%,VEGF阳性表达者MVC值(25.82±3.61)亦显著大于阴性表达者(19.65±6.32)(均P<0.05),TGFβ1、VEGF阳性表达率在乳头状癌、滤泡癌、髓样癌及未分化癌中两两比较差异均无统计学意义(P>0.05),在Ⅰ、Ⅱ、Ⅲ、Ⅳ期甲状腺癌中两两比较差异也均无统计学意义(P>0.05)。结论TGFβ1与VEGF表达与甲状腺癌组织学分型、临床分期无关,但参与甲状腺癌肿瘤血管生成过程。 Objective To investigate the relationship of the expressions of transforming growth factor β1 （TGFβ1 ）, vascular endothelial growth factor（VEGF） with angiogenesis in thyroid cancer. Method TGFβ1, VEGF and microvessel countt（MVC） were detected by immunohistochemical method in 46 thyroid cancer specimens. Results The mean MVC was significantly higher in tumors with positive TGFβ1 or VEGF than in tumors with negtive TGFβ1 or VEGF[ （26.18 ± 4,05） vs （20.13 ± 4.29） for TGFβ1 and （25.82 ± 3.61 ） vs （ 19.65 ± 6.32） for VEGF, P 〈 0.051. The expressions of TGFβ1 and VEGF did not correlate with the histological type and clinical staging of thyroid cancer. Conclusion TGFβ1 and VEGF may play an important role in the process of neovascularization in thyroid cancer.

作者王晓冰易智君朱淑玲甘启焕

机构地区惠州市中心医院病理科

出处《中国基层医药》 CAS 2006年第4期627-628,共2页 Chinese Journal of Primary Medicine and Pharmacy

关键词甲状腺肿瘤转化生长因子Β 血管内皮生长因子类肿瘤微血管计数 Thyroid neoplasms Transforming growth factor beta Vascular endothelial growth factors Microvessel count

分类号 R736.1 [医药卫生—肿瘤]

引文网络
相关文献

参考文献6

1Weidner N,Folkman J,Pozza F,et al.Tumor angiogenesis:a new significant and independent indicator in early stage breast carcinoma.J Natl Cancer Inst,1992,84(24):1875.
2Hoelting T,Zieke A,Siperstein AE,et al.Transforming growth factor beta1 is a negative regulator or differentiated thyroid cancer:studies of growth,migration,invasion,and adhesion of cultured follicular and popillary thyroid cancer cell line.J Clin Endocrinol Metab,1994,79(3):806.
3Matoba H,Sugano S,Yamaguchi N,et al.Expression of transforming growth factor beta1 type-Ⅱ receptor mRNA in papillary thyroid carcinoma.Hurm Metab Res,1998,30(10):624.
4Kimura ET,Kopp P,Zbacrcn J,et al.Expression of transforming growth factor beta1,beta2,beta3 in multinodular goiters and differentiated thyroid carcinomas:a comparative study.Thyroid,1999,9(2):119.
5Klein M,Picard E,Vignand JM.Vascular endothelial growth factor(VEGF) gene and protein:strong expression in thyroiditis and thyroid carcinoma.J Endocrinol,1999,16(1):41.
6张海燕,温滨红,杜娃,郑玮,刘国良.NF-κB与VEGF在甲状腺癌中的表达及意义[J].中国组织化学与细胞化学杂志,2004,13(2):152-157. 被引量：3

二级参考文献13

1Read MA, Whitley MZ, Williams AJ. NF-κB and IκB: an inducible regulatory system in endothelial activation. J Exp Med, 1994, 179:503-512
2Yoshida S, Ono M, Shono T. Involvement of inter-leukin-8, vascular endothelial growth factor, and basic fibro-blast growth factor in tumor necrosis factor alpha-dependent angiogenesis .Mol Cell Biol, 1997,17:4015-4023
3Kathoh R, Miyagi E, Kawaoi A. Expression of vascular endothelial growth factor (VEGF) in human thyroid neoplasms. Hum Pathol, 1999,30:891-897
4汤钊猷.现代肿瘤学 .上海医科大学出版社,1993,842-845
5Kawasaki H, Altieri DC, Lu CD. Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res, 1998, 58: 5071-5074
6Bellas RE,Gerald MJ, Fausto N. Inhibition of NF-κB activity induce apoptosis in murine hepatocytes. Am J Pathol, 1997, 151:891-896
7Dejardin E, Deregowski V, Chapelier M. Regulation of NF-kB activity by IkB-related proteins in adenocarcinoma cells. Oncogene,1999, 18:2567-2577
8Wang CY, Mayo MW, Korneluk RG. NF-kappaB anti-apoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science, 1999,281: 1680-1683
9Hinz M, Krappmann D, Eichten A. NF-kappa B function in growth control: regulation of cyclinD1 expression and G0/G1-to-S phase transition .Mol Cell Bio, 1999; 19 (4): 2690-2698
10Sovak MA, Bellas RE, Kim DW. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer . J Clin Invest, 1997,100(12): 2952-2960