摘要
目的 制备白癍搽剂并对其主要成分进行定性和定量检测。方法 以补骨脂、栀子等药材为主要原料加75％乙醇浸泡一周制成搽剂。同时采用薄层色谱法（TLC）对处方中的补骨脂、栀子进行定性鉴别，并用薄层扫描法对补骨脂素和异补骨脂素进行含量控制。结果 薄层色谱上均鉴别出制剂和各自药材的特征斑点，而空白对照色谱无此斑点；且补骨脂素和异补骨脂素在2～6μg浓度范围内线性关系良好，方法平均回收率补骨脂素为97．13％，RSD；5．84％：异补骨脂素为97．55％，RSD=5.2％。结论 制剂处方及制备工艺合理，简便；质量控制方法操作简单，重现性好，适用于该制剂的质量控制。
Objective To prepare the Baidian Tincture and control the quality of Baidian Tincture. Methods The tincture was prepared by immerging the medicinal materials in 75 % ethanol for 7 days ; psoralea eorylifolia L. and Gardenia jsminoides Ellis in the Baidian Tincture were identified by TLC,and the content was determined by TLG scanner. Results The characteristic dots of the medicinal materials were found on TLG chromatogram of the samples,but not shown in negative samples ; There was a good linear relationship from 2 to 6μg;The average recoveries of Psoralen was 97.13 %, RSD = 5.84%, and the average recoveries of isopsoralen is 97.55 %, RSD = 5.2% . Conclusions The methods are simple in operation and can be used for quality control of Baidian Tincture.
出处
《西南军医》
2006年第3期4-7,共4页
Journal of Military Surgeon in Southwest China
关键词
白癜搽剂
补骨脂
栀子
TLC
制备
质量控制
Baidian Tincture Psoralea corylifolia L Grardenia jasminoides Ellis TLC
