摘要
目的探讨氯吡格雷(波立维)长期治疗不稳定型心绞痛的疗效与安全性。方法105例不稳定型心绞痛患者随机分为治疗组(51例)和对照组(54例)。治疗组给予波立维治疗,疗程9个月。对照组不给于波立维。两组均给予阿斯匹林、低分子肝素、他汀类药物、β-受体阻滞剂和硝酸酯类药物等基础治疗。观察9个月的心血管终点事件(心源性死亡、非致死性心肌梗死和紧急血管重建)和安全性终点事件(出血、胃肠道反应和粒细胞减少)的发生率。结果治疗组9个月内联合心血管事件明显下降,两组差异具有统计学意义(P<0.05),而安全性终点差异无统计学意义(P>0.05)。结论不稳定型心绞痛患者接受氯吡格雷长期治疗疗效显著,安全可靠。
Objective To investigate the efficiency and safety of longterm treatment of Clopidogrel in patients with unstable angina. Methods 105 patients with unstable angina were randomly divided into treat group （51 cases） and eontrlo group （54 cases）, the treat group took Clopidogrel for 9 months, the control group did not dose Clopidogrel, two group toke the same basic treatment with Asprin, Low Molecular-weight Heparin, Statins, β-blockers, and Nitroglycerin. The occurrence of cardiovascular events （including cardiovascular death, myocardial infarction, and emergency revaseularisation） and safety events （hemorrhage, gastrointestinal side-effect, and granuloeytopenia） were investigated. Results The total cardiovascular events were reduced in treat group, 15.69%（treat group） vs 33.33%（control group）, P〈0.05. No significant difference was found in safety events （P〈0.05）. Conclusion The longterm treatment of Clopidogrel in patients with unstable angina is safe and effeetive.
出处
《中国现代医药杂志》
2006年第3期41-42,共2页
Modern Medicine Journal of China
