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抗菌药或糖皮质激素处理对脓毒症大鼠的治疗作用与血浆TNF-α和IL-6水平的关系研究 被引量：2

Relationship between therapeutic effects of antibacterial drugs and glucocorticoids and serum levels of TNF-αand IL-6 in sepsis rats
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摘要 采用盲肠结扎穿孔法建立脓毒症大鼠模型,观察抗菌药庆大霉素、阿莫西林和甲硝唑联合应用或地塞米松单用对脓毒症大鼠的治疗作用与血浆细胞因子TNF-α、IL-6水平变化的关系。结果显示抗菌药联合应用明显抑制脓毒症大鼠白细胞总数和中性粒细胞数增加,而地塞米松单用显著抑制白细胞总数增加和提高中性粒细胞数;两种处理均明显阻遏脓毒症大鼠血浆TNF-α和IL-6水平升高。抗菌药处理还显著降低脓毒症大鼠死亡率。本研究结果提示,虽然血浆TNF-α和IL-6水平是预测脓毒症转归的较可靠指标,但IL-6过度降低可能预示病情加重;肠源性脓毒症采用庆大霉素、阿莫西林和甲硝唑联合治疗具有最佳的治疗效果,能阻遏脓毒症大鼠血浆TNF-α和IL-6水平的持续升高,明显降低死亡率;用大剂量糖皮质激素治疗脓毒症的弊可能大于利。 Rat sepsis model was made by cecum ligation and the puncture and the relationship between therapeutic effects of combination of gentamicin, amoxicillin and metronidazole as well as dexamethasone on sepsis and TNF-α and IL-6 levels in serum was studied. It was shown that the combination of antibacterial drugs significantly suppressed rise of both white blood cell （WBC） and neutrophil, and dexamethasone only inhibited the rise of WBC. Either antibacterial drugs or dexamethasone obviously blunted the elevation of serum TNF-α and IL-6 levels in sepsis. However, only antibacterial drugs clearly decreased mortality. All above findings indicated that serum TNF-α and IL-6 levels may be reliable parameters for prognosis of sepsis, but over decreasing IL-6 level may be a signal of sepsis deterioration.
作者 熊缨 袁野 徐蜀远 余丽梅 周岐新
机构地区 重庆医科大学 自贡市第三人民医院
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2006年第5期298-302,共5页 Chinese Journal of Antibiotics
关键词 脓毒症 抗菌药 糖皮质激素 肿瘤坏死因子-α 白介素-6 Sepsis Antibacterial drugs Glucocorticoids Tumor necrosis factor-α Interlukin-6
分类号 R965 [医药卫生—药理学]
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参考文献21

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共引文献69

同被引文献54

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中国抗生素杂志
2006年 第5期

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