摘要
目的研究乳腺癌组织X染色体连锁的凋亡抑制蛋白(X IAP)和survivin基因变化规律,探讨两者预测乳腺癌复发的价值。方法应用免疫组织化学方法检测6 5例良、恶性乳腺病变组织中X IAP和survivin的表达,并比较其阳性表达率的差异。结果复发乳腺癌(复发组)两指标的阳性率依次为8 2.2%和8 5.7%,无复发乳腺癌组织(无复发组)依次为5 4.5%和4 5.5%;两组的X IAP和survivin阳性表达率均高于乳腺纤维腺瘤组织的2 0%和1 3.3%。复发组X IAP,survivin阳性表达明显高于无复发组(P<0.0 1)。复发组X IAP表达与组织学分级呈正相关(r=0.4 7 2,P<0.0 5),与激素受体呈负相关(r=-0.4 8 6,P<0.0 5);survivin表达与组织学分级亦呈正相关(r=0.5 3 2,P<0.0 5);X IAP表达与survivin表达呈正相关(r=0.4 4 7,P<0.0 5)。结论X IAP和survivin可能在乳腺癌的发生、发展过程中起重要作用。联合检测两指标可能更好地判断乳腺癌的预后。
Objective To study the expressions of XIAP and survivin in breast carcinoma tissues and their value in predicting the recurrence of breast carcinoma. Methods The expression of XIAP and survivin in 65 benign and 65 malignant breast paraffin-embedded specimens was detected by using immunohistochemical assay and the results were compared. Resuits The positive rate of XIAP and survivin in recurrent breast carcinoma （recurrent group ） was 82. 2 % and 85. 7 % respectively, and in non-recurrent breast carcinoma tissue （ non-recurrent group ） was 54.5 % and 45.5 % respectively, and in both groups were increased significantly as compared with that of benign breast tissues（ 20.0% , and 13.3% respectively）. The positive expression of XIAP and survivin was increased significantly in recurrent group as compared with non-recurrent group （ P 〈 0.01 ）. In recurrent group, XIAP expression had a positive correlation with histologic grade （ r = 0.472, P 〈 0.05 ） , but negative correlation to estrogen and progesterone receptors （ r = - 0. 486, P 〈 0.05 ） ; survivin expression also had a positive correlation with histologic grade（ r = 0. 532, P 〈0. 05 ） ;MAP and surviving expression had positive correlation （ r = 0. 447, P 〈 0. 05 ）. Conclusions XIAP and survivin oncogene may play an important role in the development of breast cancer, and suggests that their combined detection is valuable for better prediction of the prognosis of breast cancer.
出处
《中国普通外科杂志》
CAS
CSCD
2006年第4期253-256,共4页
China Journal of General Surgery
