摘要
目的探讨肝素对妊娠中晚期脐动脉血流异常的影响,以便寻找改善脐动脉血流异常的有效治疗方法。方法采用脐动脉血流收缩期最大血流速度(S)与舒张末期血流速度(D)的比值,将脐动脉血流S/D比值大于相应孕周的第95百分位以上的83例妊娠中晚期妇女共85例胎儿(2例双胎)分为研究组(41例孕妇,42例胎儿)和对照组(42例孕妇,43例胎儿)。研究组应用肝素6 250 u+5%葡萄糖500 mL;对照组应用低分子右旋糖酐500 mL,丹参30 mL+10%葡萄糖500 mL。定期复查脐动脉血流S/D比值(每天1次)。结果研究组平均每天脐动脉血流S/D比值下降0.39,对照组平均每天脐动脉血流S/D比值下降0.12,两组结果比较差异具有显著性(t=3.45,P<0.05)。研究组所需治疗时间显著短于对照组(3.5±2.7 vs 7.3±3.1d),两组比较差异具有显著性(t=5.83,P<0.01)。研究组脐动脉血流S/D比值下降率为100%,对照组为68.3%,两组比较差异有统计学意义(χ2=4.12,P<0.05)。结论肝素可显著改善妊娠中晚期脐动脉血流异常,效果显著,疗程缩短,值得推广。
Objective To evaluate the efficiency of heparin on the ratio of peak systolic to least diastolic flow velocity （S/D）of umbilical artery flow velocity waveforms at second or third - trimester pregnancies and search for the effective clinic treatment method. Methods Eighty - three pregnant women carrying 85 fetuses（2 twins）whose fetal umbilical artery flow S/D ratios were more than the 95th percentage were divided into the study group and the control groups. In the study group,41 women carrying 42 fetuses were treated with heparin at a dose of 6 250 u ＋ 5 % Gloucose 500 mL intravenously per day. In the control group, another 42 women with 43 fetuses were treated regularly with dextran 40 500 mL, rooted salvia 30 mL＋ 10% glucose 500 mL. After treatment, the S/D ratios were reexamined and compared between two groups. Results The mean of decreased S/D ratios per day in the heparin group and the control group was 0.39 and 0.12 respectively. There was significant difference between two groups （ t = 3.45, P 〈 0.05 ）. The treatment time was significantly shorter in heparin group than in the control （ t = 5.83, P 〈 0.01 ） ）. The effective rate was significantly higher in heparin group than in the control （ 100% vs 68.3%, x^2 = 4.12, P 〈 0.01 ）. Conclusions Heparin can significantly decrease the high S/D ratios of umbilical artery flow velocity waveforms at second or third - trimester of pregnancy, improve the pregnancy and shorten the hospitalized days.
出处
《南华大学学报（医学版）》
2006年第1期94-96,共3页
Journal of Nanhua University(Medical Edition)
关键词
肝素
脐动脉
妊娠中晚期
heparin
umbilical arteries
second or third- trimester pregnancy
