摘要
目的回顾分析和比较后程加速超分割放疗(后超组)与常规分割+腔内放疗(腔内组)食管癌的疗效。方法对1994年5月至1999年11月间4个小样本前瞻性研究的后超组(135例)和腔内组(130例)治疗食管癌的病例进行分析比较。后超组前3周常规分割照射3000cGy(分15次3周完成),后2周采用加速超分割照射3000cGy(分20次2周完成;150cGy/次,2次/d,2次相隔6h,5d/周)。腔内组常规分割照射5000cGy(分25次5周完成)+腔内照射1000cGy(分2次)。结果后超组和腔内组1、3、5年总生存率分别为61.8%、27.9%、19.9%和53.5%、25.2%、18.4%(P>0.05)。后超组和腔内组急性放射性食管炎的发生率分别为61.5%和57.0%(P=0.235),且RTOG分级3级食管炎比较两组差异也无统计学意义。结论两种放疗方式食管癌的生存率无明显差别,但后程加速超分割技术操作方便,易于在临床中实施。
Objective To analyze and compare retrospectively the results of esophageal carcinoma treated with late course accelerated hypeffractionation radiotherapy（LCAHR） and conventional fractianation radiotherapy plus brachytherapy（CFRB）. Methods From May 1994 to November 1999, 265 patients from four independent prospective studies were included in the analysis. 135 patients treated by conventional fractionafion radiotherapy with 3000 cGy/15f and then hyperfractionation radiotherapy（ 150 cGy/d, twice） with 3000 cGy/20f in the LCAHR group, and 130 patients by conventional fractionafion radiotherapy with 5000 cGy/25f plus brachytherapy with 1000 eGy/2f（ with a 6 hour interval） in the CFRB group. Results The 1-,3-,5-yearsurvival rate was 61.8%, 27.9 %, 19.9% and 53.5 %, 25.2 %, 18.4% in LCAHE and CFRB group, respectively （ P 〉 0.05）. Acute eeophagitis occurrence rate was 61.5% and 57.0% in LCAHE and CFRB group, respectively（ P =0.235）, and grade Ⅲ esophagitis occurrence rate without any difference in the two groups. Conclusions The survival results show no difference between LCAHR and CFBB group. The technique of late course accelerated hyperfractionation radiotherapy, being easy to arrange, can be more easily carried out in clinical practice.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2006年第3期182-184,共3页
Chinese Journal of Radiation Oncology
基金
河北省科技厅科研基金资助(99276144D)
