摘要
目的:考察氟脲嘧啶脱氧核苷与7种不同输液配伍的稳定性。方法:将氟脲嘧啶脱氧核苷按临床常规剂量加入输液中,放置在不同温度(25,35℃)下,用高效液相色谱法测定配伍后不同时间点输液中氟脲嘧啶脱氧核苷的含量,同时观察外观性状、pH、紫外吸收光谱和 HPLC 色谱图的变化。结果:不同温度条件下,氟脲嘧啶脱氧核苷与7种常用输液的配伍溶液在120 h内性状、pH(RSD<2%)和氟脲嘧啶脱氧核苷的含量(RSD<2%)、紫外吸收光谱和 HPLC 色谱图无明显变化。结论:氟脲嘧啶脱氧核苷与7种常用输液配伍至少在观察的120 h 内稳定。
Objective ：To observe the stability of floxuridine injection in infusion solution. Methods：To determinate the content of floxuridine in 7 kinds of infusions using RP - HPLC, the color and clarity were assessed, and pH was measured at 25 % and 35 % for 120 h, in the meantime, to inspect the change of ultraviolet absorption spectrum utilizing diode array detector and observe the change of chromatogram. Results：All solution were no or few changes in the appearance,pH,content,ultraviolet absorption spectrum and chromatogram at 25℃ and 35℃ for 120 h. Conclusion：The floxuridine injection in infusion solutions kept relatively stability in 120 h.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2006年第4期469-472,共4页
Chinese Journal of Pharmaceutical Analysis
