摘要
目的检测新生儿缺氧缺血性脑病（HIE）患儿血清IgG、IgA、IgM的变化，以了解HIE患儿体液免疫功能的变化。方法67例HIE患儿根据出生后的日龄和病情轻重分为1-3天组32例，其中轻度HIE14例，中重度HIE18例；4～6天组35例，其中轻度HIE16例，中重度HIE19例。对照组30例新生儿为同期我院产科出生的正常新生儿。采用散射免疫扩散法对HIE患儿和对照组进行体液免疫指标IgG、IgA、IgM的检测，相关结果进行统计学分析。结果在1—3天组，IgG、IgA、IgM在对照组、轻度HIE组和中重度HIE组3组间比较无显著性差异（P〉0．05）。在4—6天组，IgG、IgA、IgM在对照组、轻度HIE组和中重度HIE组3组间比较亦无显著性差异（P〉0．05）。结论HIE患儿体液免疫功能无明显变化。
Objieetive To detect the changes of serum IgG, IgA and IgM in neonates with hypoxic ischemic encephalopathy （HIE）. Methods Sixty- seven neonates with HIE and thirty normal full - term infants were recruited in the study. According to the characteristics of immunological function and the degree of HIE, the neonates were divided into 1 - 3 day group （n =32） and 4- 6 day group （n = 35）, and each of them was further divided into a mild group and a moderate- severe group. The immunoglobulin （Ig） in serum was examined by radial immunodiffusion assay with Behring Nephelometer 100 Analyzer. Results In the 1 - 3 day group, the levels of IgG, IgA and IgM in HIE group were not obviously diffexent from that in the control group （ P 〉 0.05）. In the 4 - 6 day group, these levels did not differ from the control either （ P 〉 0.05）. Conclusion The levels of IgG, IgA and IgM in serum are not obviously affected by HIE in neonates.
出处
《徐州医学院学报》
CAS
2006年第3期219-221,共3页
Acta Academiae Medicinae Xuzhou
基金
江苏省教育厅自然科学基金指导性课题(99KJD320001)
关键词
缺氧缺血性脑病
新生儿
体液免疫
hypoxic ischemic encephalopathy
newborn
fluid immunity
