摘要
尿酸结石是指尿酸及其盐在泌尿系统的异常矿化和积聚。本文从尿酸结石研究中涉及的化学问题入手,讨论了pH、过饱和度、尿大分子抑制剂和基因突变等方面对尿酸结石形成的分子机理,从抑制尿酸结石成核、生长和聚集的角度,讨论了尿酸结石的化学模型和动物实验模型。
Uric acid stone is referred as the abnormal biomineralization and aggregation of uric acid and urates. In this paper, the chemical problems and molecular mechanisms in the formation of uric acid stones were discussed from the points of pH, supersaturation, urinary macromolecule inhibitors and gene mutation etc. The chemical models and animal experiment models of uric acid stones were also discussed from the points of nucleation, growth and aggregation of uric acid crystals.
出处
《化学通报》
CAS
CSCD
北大核心
2006年第5期382-387,共6页
Chemistry
基金
国家自然科学基金(20471024)
广东省科技攻关(2005B30701003)
中国科学院有机固体实验室开放基金资助项目
关键词
尿酸
泌尿系结石
生物矿化
Uric acid, Urinary stone, Biomineralization
