摘要
目的:探讨非瓣膜病心房颤动(房颤)对内皮功能的影响。方法:选择中老年非瓣膜病房颤患者92 例(房颤组)和窦性心律者60例(对照组),采用放射免疫分析法(RIA法)测定血浆内皮素-1(ET-1)和6-酮-前列腺素F1α(6-k-PGF1α)水平,采用酶联免疫吸附双抗体夹心法(ELISA法)测定血浆血管性血友病因子(vWF)水平,观察2组间各指标的差异,并对可能影响ET-1、vWF、6-k-PGF1α水平的性别、年龄和血清肌酐、尿酸、血糖、三酰甘油、胆固醇等因素采用协方差方法分析。结果:①单因素分析,房颤组ET-1(115．11±81．84)ng／L显著高于对照组(83．81±20．60)ng／L,P<0．05,房颤组vWF(163．04±36．58)％也显著高于对照组(71．14±43．40)％, P<0．01,房颤组6-k-PGF1α(205．81±100．96)ng／L显著低于对照组(300．79±118．02)ng／L,P<0．01。②多因素分析,调整其他可能影响因素后,房颤组ET-1和vWF水平仍高于对照组(P>0．05和P<0．01),6-k- PGF1α水平仍低于对照组(P<0．05)。结论:非瓣膜病房颤患者存在内皮细胞受损和功能异常。因此应重视非瓣膜病房颤患者改善内皮功能的治疗。
Objective： To investigate the influence of nonvalvular atrial fibrillation （Af） on endothelial function. Method： The plasma concentrations of endothelin-1 （ET-1） and 6-keto-prostaglandin F1α （6-k-PGF1α） were measured by radioimmunoassay （RIA） and the plasma concentration of yon Willebrand Factor （vWF） was measured by enzyme linked immunoadsorbent assay （ELISA） in 92 middle-old aged patients with nonvalvular Af （Af group） and 60 middle-old aged patients with sinus rhythm （control group） . The differences between 2 groups were determined by univariate analysis and multivariate analysis. Result： ①The plasma concentrations of ET-1 （[115.11 ± 81.84]ng/Lvs E83.8±20.60]ng/L, Pal0.05） and vWF （[163.04±36.58]% vs [71.14±43.40]%, P 〈0. 001） in Af group were significantly higher than those in the control group by univariate analysis, while the plas ma concentration of 6-k-PGF1α, in Af group was significantly lower than that in the control group （E205.81 ± 100.96] ng/L vs [300.79±118.02]ng/L, P〈0.01）.② After adjustment of the factors of sex, age and plasma levels of creatinine, uric acid, blood sugar, triglyceride and cholesterol, the plasma concentrations of ET1 （ P〉 0. 057 and vWF （ P 〈0. 017 in AF group were still higher while 6-k-PGF1α （ P 〈0. 01） in Af group lower than those in the control group respectively with analysis of covariance. Conclusion; Endothelial damage/dysfunction were found in the patients with nonvalvular Af. More attention should be paid to the improvement of endothelial function in the patients with nonvalvular Af.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2006年第5期270-272,共3页
Journal of Clinical Cardiology
基金
卫生部保健科研基金(NO:2001012)
