摘要
首次在毛细管电泳（ＣＥ）中分别用三种不同类型环糊精（ＣＤｓ）作手性选择子对十种手性药物进行拆分，并拟通过不同药物的手性拆分情况比较。
compounds were chirally separated by adding α ,β , γ cyclodextrin as chiral selector respectively. Due to the different cavity sizes, α ,β ,γ CD have selectivities to the vip moleculars with different sizes and shapes, and the “size match” principle and complexation between CDs and the vip moleculars was introduced to explain the experimental results. The chiral recognition mechamism was further proved.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1996年第6期363-365,共3页
Journal of China Pharmaceutical University
关键词
环糊精
手性药物
毛细管电泳
Cyclodextrins
Host vip complexation
Size match principle
Chiral drugs
Chiral separation
Capillary electrophoresis
