摘要
选择TT及BT型麻风33例,用S—100蛋白免疫组化(ABC)法检测,有28例可在肉芽肿内见到遭受不同程度破坏的神经,包括神经纤维肿胀、变形和断裂成碎片,阳性率为85％;在作对照的4例结节病和2例皮肤结核中,S—100蛋白阳性的神经均位于肉芽肿外,且结构完整。因此作者认为S—100蛋白染色对诊断PB型麻风,特别是在HE和抗酸染色阴性时,有重要的诊断价值。
Thirty three cases of TT and BT leprosy were examined Dy the ABCmethod of S- 1 00 protein. The nerves in epithehoid cell granulomas were markedly destroyed in 28 cases, being swollen, deformed and broken, making up 85% and no nerve in five cases was seen. In contrast, the sections of four cases of sarcoidoses and two cases of cutaneous tuberculosis showed that the S- 100 protein positive nerves were located outside the granulomas and kept their normal structures. The anthors believe that the S- I 00 protein stain technique is valuable to diagnosing paucibacillary leprosy when the diagnoses can not be confirmed with HE stain histopatho-logically.
