摘要
为观察乙型肝炎后肝硬化患者体内ＨＢＶ的复制状况，为抗病毒治疗提供依据，以减少盲目用药。应用多聚酶链反应，对２６例乙型肝炎后肝硬化患者检测了血清ＨＢＶ－ＤＮＡ存在状态。结果显示，活动性乙型肝炎后肝硬化９例，血清ＨＢＶ－ＤＮＡ阳性８例，阳性率８８．８８％，静止性乙型肝炎后肝硬化１７例，ＨＢＶ－ＤＮＡ脑性６例，阳性率３５．２９％。两组比较。血清ＨＢＶ－ＤＮＡ阳性率差异显著（Ｐ＜０．０１）。结果表明，应重点对活动性乙型肝炎后肝硬化患者进行抗病毒治疗。
Hepatitis B virus(HBV) DNA in serum was detected by the polymerase chain reaction in 26post-hepatitis B cirrhosis. The results showed that HBV-DNA was positive in 8 of 9(88. 88 % )HBeAg positive,in 6 of 17(35. 29 %) anti- HBe positive sera ,respectively. The positive rates of HBV- DNA were significantly higher in active posthepatitis B cirrhosis than those in silent post-hepatitis B cirrhosis. Antiviral therapy should be taken in patients with active post-hepatitis B cirrhosis.
出处
《滨州医学院学报》
1996年第5期434-434,共1页
Journal of Binzhou Medical University
关键词
多聚酶链反应
乙型肝炎
HBV-DNA
肝硬变
hepatitis B virus DNA
polymerase chain reaction
post-hepatitis B cirrhosis
