摘要
为研究小肝细胞癌（ＳＨＣＣ）与大肝细胞癌（ＬＨＣＣ）细胞生物学特征的差异，采用ＱＤＡ软件分析系统对１１例ＳＨＣＣ和２０例ＬＨＣＣ作ＤＮＡ定量比较。结果显示，８例（７２．７％）ＳＨＣＣ为二倍体细胞（２Ｃ）型，１９例（９５．０％）ＬＨＣＣ是异倍体（ＡＮ）型（Ｐ＜０．０１）。１７例（８５．０％）ＬＨＣＣ的ＤＮＡ直方图为多峰曲线，而９例（８１．８％）ＳＨＣＣ为单峰曲线（Ｐ＜０．０１）。结果表明，ＳＨＣＣ主要为单细胞克隆２Ｃ肝癌，而ＬＨＣＣ多为ＡＮ肝癌，且其细胞克隆以异质性表现为主。
To study the biologicaf characteristics of small hepatocellular carcinoma(SHCC) and large hepatocellular carcinoma(LHCC),the DNA centent of 11 SHCC and 20 LHCC was guantitatively determined by means of QDA-image analysis. The results showed that 8(72. 2%)SHCC had DNA cell line in diploid(2C),and 19(95. 0%) LHCC had DNA cell line in aneuploid(AN)(P<0. 01). The multipeak histogram of DNA content in LHCC was 85. 00%,but the single peak histogram in SHCC was 81. 80% (P<0.01 ). The results suggest that the majority of SHCC is monoclonal 2C cell line,and LHCC is mainly AN cell line with heterogeneity.
出处
《滨州医学院学报》
1996年第5期428-429,共2页
Journal of Binzhou Medical University
关键词
DNA
肝细胞癌
图象分析
DNA, hepatocellular carcinoma
image analysis
