摘要
目的:探讨单侧输尿管部分梗阻后肾小球滤过率(GFR)的变化规律及梗阻解除后早期的恢复状况,分析血管紧张素在梗阻性肾功能损害中的作用。方法:30只实验用大白兔分为对照组6只和梗阻组24只。采用Cheng’法制作右侧输尿管部分梗阻模型。在梗阻1,2,4和8周后,分别选6只应用SPECT检查肾小球滤过率及肾图,嗣后处死3只留取肾静脉血测定血管紧张素转换酶(ACE)水平并行肾脏组织学检查,另3只解除梗阻,4周后再次检查。结果:输尿管部分梗阻后GFR进行性下降,梗阻1周下降18.12%,以后明显减慢;血清ACE在梗阻后4周内显著升高,8周时降至对照组水平。梗阻解除后4周双肾GFR略有上升,ACE未再有变化。结论:输尿管部分梗阻后GFR降低,以早期最为显著,梗阻解除后4周缓慢上升。梗阻造成的肾功能损害与RAS系统的活化有关,阻断RAS活性可能会对梗阻肾功能有保护作用。
Objective： To investigate the degression rule of glomerular filtration rate（GFR） in rabbits with partial unilateral ureteral obstruction and its early role of renin-angiotensin system （RAS） in the experimental rabbits were randomly divided int recovery after reversal of obstruction, and to analyze the damage of obstructed kidney function. Methods： Thirty o the control and obstructed group. Twenty-two models of right partial ureter obstruction were established by Cheng＇s method. Six animals were assayed by 99- technetium diethyleneera- minepentaacetate （^99m Tc-DTPA） glomerular filtration rate renal scan at 1-, 2-, 4-, or 8-week after obstruction respectively, while three of the six animals were released the obstruction and reinspected after four weeks. Angiotensin-convertion enzyme（ACE） level in renal vein was measured simultaneously. Results： The GFR of obstructed kidney was decreased progressively, which reduced by 18. 12% during the first postoperative week and then dropping slowly. The ACE level was increased significantly in the first four weeks, and then returned to the level of control. After relief of the obstruction, renal function was improved to small extent and the ACE level was maintained. Conclusion： GFR degrades predominantly at the early period after partial unilateral ureteral obstruction, and improves slowly after release of obstruction. RAS may contribute to this damage and may be one of the starting factors.
出处
《武汉大学学报（医学版）》
CAS
2006年第3期399-401,405,共4页
Medical Journal of Wuhan University
关键词
输尿管梗阻
肾小球滤过率
血管紧张素
Ureteral Obstruction
Glomerular Filtration Rate
Angiotensin
