摘要
目的对比研究卡维地洛与美托洛尔两种不同类型的β受体阻滞剂在治疗不同时期对充血性心力衰竭左室收缩功能的影响。方法将64例充血性心力衰竭患者在常规心衰治疗基础上随机分为卡维地洛组(A组,n=33)和美托洛尔组(B组,n=31),应用超声心动图分别于治疗前、治疗6个月、治疗12个月时测量左心室短轴缩短分数(FS)、左心室射血分数(LVEF)结果①两组治疗6个月时,左室收缩功能与治疗前比较,均有显著改变;A组LVEF改变较B组显著;②治疗12个月与6个月比较,A组LVEF改善显著。结论随着治疗时间的延长,卡维地洛在改善左心室射血分数方面较美托洛尔更显著,显示了新一代β受体阻滞剂在治疗充血性心力衰竭的优越性。
Objective To compare the different influence to left ventricular function of the two kinds of β-blockers carvcdill and metrolol in chronic heart failure（CHF） patients at different stages.Methods 64 cases of CHF are divided into two groups freely, besides the normal medicine, one group was given carvedilol（ Group A n = 33）, while the other group was given metrolol （ Group B n = 31 ）. Left ventricular function was calculated by measure the left ventrieular PS and LVEF with ultrasonic eaediograph in the beginning and after 6 months and 12 months of the treatment.Result ①Left ventrieular contraction was distinctive improved in both groups, and rite LVEF in Group A was more improved than Group B.②In Group A,the LVEF improved much more after.12 months than at 6 months of treatment. Conclusion Carvedilol shows better effect than metrolol in improving LVEF in the treatment of CHF,and can get much more benefits when a longer time it was used,which shows its advantage in the treatment of CHF.
出处
《广西医学》
CAS
2006年第3期336-338,共3页
Guangxi Medical Journal
基金
广西科学研究与技术开发计划项目基金资助项目(编号:桂科攻2350242)
