摘要
本文以手性α-异丙基对氯苄胺为手性诱导试剂和取代苯甲醛生成的席夫碱与亚磷酸酯进行不对称加成反应,生成具有双手性中心的N-取代-α-氨基膦酸酯。化学产率为40～91％,de％可达到72％。并简单讨论了立体效应对光学诱导能力的影响。
Chiral N - substituted - α - aminophosphonates were synthesized stereoselectively by addition of dialkylphosphites and chiral imines, using ( S ) - α - iso - propylbenzylamine as chiral inducing agent. The de was up to 72 % and yields were 30 - 90 % . The stereoeffects on the optical and chemical yields were discussed briefly.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1996年第3期238-241,共4页
Chinese Journal of Organic Chemistry
关键词
不对称合成
席夫碱
光学活性
氨基膦酸酯
asymmetric synthesis, chiral imine, N - substituted - α - aminophosphonate
