摘要
FADD是Fas系统的一个信号连接蛋白,是死亡受体与胞浆成分之间联系的纽带,可将膜表面受体与胞浆中细胞凋亡的终末酶联接起来,从而向胞内传递凋亡信号,介导细胞凋亡,与多种疾病过程有关。同时,FADD在T细胞增殖中也起一定的作用。现就有关FADD与细胞凋亡、T细胞增殖以及在疾病中作用的研究进展加以综述。
FADD is a signal connectin in Fas-FasL apoptotic path, which is the vinculum between death receptor and endochylema elements. FADD might play a key role on apoptosis by transferring apoptotic signal from conjugating membrane surface receptor with endochylema apoptotic enzyme into cells. Meanwhile, FADD also might associate with T calls proliferation. This article is a research progress review about the relationship among FADD, cell apoptosis, and cell proliferation.
出处
《国际免疫学杂志》
CAS
2006年第3期152-156,共5页
International Journal of Immunology
关键词
FAS相关死亡结构域蛋白
细胞凋亡
细胞增殖
Fas associated protein with death domain, FADD
Cells apoptosis
Cells proliferation
