摘要
目的:探讨瘦素(leptin)、瘦素受体(leptin receptor)在胃癌发生发展中的意义及其相互关系。方法:应用免疫组织化学SP法检测19例正常胃黏膜、19例慢性萎缩性胃炎伴肠化、18例不典型增生、15例早期胃癌、45例进展期胃癌组织中leptin、leptin receptor表达情况。结果:leptin随胃癌的发展阳性率逐渐增高(15.8%,31.6%,44.4%,53.3%,80.0%;P<0.01);leptin表达与组织学分级、浆膜浸润、淋巴结转移和TNM分期有关(P<0.05)。leptin receptor阳性表达率在胃癌发展过程中差异无显著性(P>0.05)。leptin和leptin receptor在胃癌组织中的表达无相关性(rs=-0.005,P>0.05)。结论:leptin、leptin receptor共同参与了胃癌的发生与发展。
Objective：To evaluate the roles of leptin and leptin receptor in the development of gastric carcinoma （GC） as well as their interrelation. Methods：Sreptacidin/peroxidase （SP） technique was adopted to examine the expressions of leptin and leptin receptor in 19 cases of normal gastric mucosa, 19 cases of chronic atrophic gastritis with intestinal metaplasia （CAG＋IM）, 18 cases of atypical hyperplasia（Dys）, 15 cases of early gastric carcinoma and 45 cases of advanced gastric carcinoma. Results：With the development of GC, the positive rate of leptin was increased gradually （ 15. 80%, 31. 60%, 44. 40%, 53. 30%, 80. 0% ; P 〈0. 01 ）. Leptin positive expression was correlated with the histologic stage, serosa infiltration,lymph node metastasis and the TNM stage （P〈0.05）. With the development of GC, the positive rate of leptin receptor was varied unobviously （P〉0.05）. There was no relationship between leptin expression in the GC and that of leptin receptor （rs=- 0. 005, P〉 0. 05）. Conclusion：Leptin and leptin receptor contributed to the development of GC.
出处
《中国误诊学杂志》
CAS
2006年第9期1634-1636,共3页
Chinese Journal of Misdiagnostics
基金
河南省重点科技项目(编号:0124170505)
关键词
胃肿瘤/病理学
瘦素/代谢
受体
细胞表面/代谢
免疫组织化学
Stomach neoplasms/pathology
Leptin/metabolism
Receptors, cell surface/metabolism
lmmunohistochemitry
