摘要
目的阐明群体性预防接种反应与季节性呼吸道传染病的判别,为处理群发性事件提供借鉴。方法开展流行病学调查,进行临床诊断与血清学(病原学)分离鉴定,病原学采用MDCK法进行病毒分离。结果流行病学调查显示接种甲型肝炎疫苗与否和发病率无相关关系;患者临床症状、体征类似上呼吸道感染;从24例患者中分离到A型流感病毒8株,分离阳性率为33.3%。结论该宗群体性发热是流行性感冒的局部小流行,而非接种甲型肝炎疫苗反应。从而排除了一起接种甲型肝炎疫苗偶合群体性热病引起的纠纷,为今后鉴别预防接种后不良事件提供参考,消除该事件对计划免疫/扩大免疫接种的负面影响。
Objective To distlnghish between the side effects caused by immunization and the illness caused by the seasonal respiratory tract infection. Method Epidemiological technics and serological methods were used in this study. MDCK cells were used for virus isolation and identification. Result Results from epidemiological study indicated that there was no association between vaccination with hepatitis A vaccine and the occurrence of hepatitis. The clinical manifestations of the sufferers were similar to upper respiratory tract infection. 8 out of 24 patients （33.3%） had the infection by influenza A virus. Conclusion This is a small flu epidemic rather than the adverse reaction caused by immunization. Through this epidemiological study, a dispute on the adverse effects caused by immunization was avoided.
出处
《热带医学杂志》
CAS
2006年第4期452-454,共3页
Journal of Tropical Medicine
关键词
预防接种
甲型肝炎疫苗
流行性感冒
population immunization
hepatitis A vaccine
influenza
