摘要
目的观察还原型谷胱甘肽(G SH)治疗急性感染性疾病所致肝功能损害的临床疗效。方法将肝损害患者138例随机分为G SH组70例和对照组68例。G SH组给予0.9%氯化钠溶液250m l+G SH 1 200m g静滴,每天1次;对照组给予0.9%氯化钠溶液250m l+门冬氨酸钾镁20m l+V itC 2g+V itB6100m g+肌苷400m g静滴,每天1次。疗程均为2周,分别对比用药后的肝功能指标变化情况。结果两组治疗后第2周末ALT、A ST、γ-GT、ALP值较治疗前显著降低(P<0.01或P<0.05),但G SH组ALT、A ST值较对照组下降更为明显(P<0.05),ALT、A ST治愈率较对照组高(P<0.05)。结论G SH治疗急性感染性疾病所致肝功能损害近期疗效显著、安全。
Objective To observe the clinical efficacy of glutathione （GSH） in the treatment of hepatic dysfunction caused by acute infectious diseases, Methods A cohort of 138 cases of hepatic dysfunction was divided randomly into GSH group （70 cases） and control group （68 cases）. Patients in GSH group were treated wit h 1 200 mg GSH dissolved in 250 ml saline （iv gtt, qd） for 2 weeks and those in control group were given 20 ml sparagin＋2g vitamin C ＋ 100mg vitamin B6＋400 mg earnine dissolved in 250 ml saline（iv gtt, qd） for 2 weeks. The marks of hepatic function were tested and compared before and after treatment. Results The level s of ALT, AST,Y-GT, and ALP were markedly reduced after 2 weeks＇ treatment in the two groups （P〈0. 01 orP〈0. 05）. The levels of ALT and AST were much lower and the recovery rates of ALT and AST were higher in GSH group than control group （P〈0. 05）. Conclusion GSH is effective and safe in the treatment of acute infectious diseases-induced hepatic dysfunction.
出处
《西部医学》
2006年第3期311-312,共2页
Medical Journal of West China
