摘要
目的通过对不同类型便秘患者直肠敏感性的研究,比较两者病理生理机制上的异同。方法对功能性便秘和便秘型-肠易激综合征(IBS)患者直肠敏感性进行检测,通过Barostat采用500ml的聚乙烯囊对直肠进行快速时相性扩张,同时选择正常健康人作对照组。结果功能性便秘患者直肠排便窘迫阈值和最大耐受阈值(22.61mmHg±10.03mmHg,32.11mmHg±9.73mmHg)较对照组(14.64mmHg±4.20mmHg,25.18mmHg±5.38mmHg)明显增高,便秘型-IBS初始感觉阈值较对照降低(5.58mmHg±3.48mmHg比8.81mmHg±5.90mmHg)。两者间比较发现便秘型-IBS较功能性便秘各项感觉阈值均显著降低。三组间直肠、肛管的静息压和最大缩榨压比较未见明显异常。结论直肠感觉迟钝是便秘的一个重要的病理生理机制,在功能性便秘中更常见;IBS-便秘型直肠感觉过敏占有更重要的地位。
Objective To investigate the differences of the rectal sensitivity between functional constipation （FC） and constipation-predominant IBS （C-IBS）. Methods The rectal sensitivities in patients with FC, C-IBS and healthy controls were tested by a computerized Barostat with a 500ml polyethylene bag,and the pressure was controlled by rapid phasic distention. Results The pressures of urgency and pain in FC patients （22.61 ± 10.03 mmHg; 32.11 ± 9.73 mmHg） were significantly higher than those in controls （14.64 ± 4.20 mmHg; 25.18 ± 5.38 mmHg）. However, comparing with healthy volunteem,the first perception in C-IBS patients was significantly decreased （5.58 ± 3.48mmHg vs. 8.81 ± 5. 90mmHg）. The pressures of all sensation were significant decreased in C-IBS patients, compared with FC. There is no difference in rectal resting pressure, anal resting pressure and anal squeeze pressure among the three groups. Conclusion Rectal hyposensitivity is an important pathogenesis of FC, hypersensitivity is popular in C-IBS.
出处
《临床内科杂志》
CAS
2006年第5期317-319,共3页
Journal of Clinical Internal Medicine
