摘要
目的观察前列腺素E1(PGE1)对急性坏死型胰腺炎犬的作用,并探讨其对重症急性胰腺炎 (SAP)患者的治疗效果。方法制备急性坏死型胰腺炎犬模型,并用PGE1进行干预,测定胰背动脉和肠系膜上动脉血流量及血清淀粉酶活性,观察病理组织学改变。采用前瞻性、对照、开放试验,将确诊为 SAP的患者分为PGE1治疗组和丹参对照组,检测血清淀粉酶、乳酸脱氢酶、血清C-反应蛋白,并进行 APACHEⅡ评分、SIRS评分、Binder合并症评分和CT评分。结果 PGE1可提高胰腺组织血液流量,明显减少胰腺组织的损伤和炎症反应。PGE1治疗组较丹参对照组血清淀粉酶恢复正常时间缩短。PGE1脂微球较丹参在不同时间点能更明显改善APACHEⅡ评分、SIRS评分、CT评分。结论 PGE1对重症急性胰腺炎具有一定的治疗作用。
Objective To study the role of prostaglandin E1 （PGE1） in dogs with acute necrotic pancreatitis （ANP）, and its efficacy in patients with severe acute pancreatitis （SAP） . Methods Canine model of ANP was established by injection with 5% sodium taurocholate, and the animals were treated with either lipo-prostaglandin E1 or dan-shen. Blood flow of back pancreatic artery and superior mesenteric artery, serum amylase activity, histologic changes were assessed. In the prospective, open-labelled, and controlled clinical trial, patients with SAP were enrolled and divided into PGEl-treatment group and dan-shen control group. Serum amylase activity, lactate dehydrogenase activity and CRP were determined. The severity of SAP was evaluated based on Ranson＇s criteria, APACHE- Ⅱ , SIRS, Binder＇ s criteria and Balthazar CT scoring. Results PGE1 improved blood flow of pancreas and reduced trauma and inflammatory reaction of the pancreas. Compared with dan-shen control group, recovery time of serum amylase was shortened, Ranson＇s criteria, APACHE- Ⅱ , SIRS, and Balthazar CT scoring at different times were significantly improved in patients treated with PGE1. Condusion PGE1 might have some therapeutic effects in SAP.
出处
《中华急诊医学杂志》
CAS
CSCD
2006年第5期433-436,共4页
Chinese Journal of Emergency Medicine
基金
上海市科技启明星后基金资助项目(99Q814009)
