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血管生成素的结构与功能的研究进展 被引量：3

The Progress in the Structure and Function of the Angiogenin
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摘要 血管生成素(angiogenin,ANG)是一种有效的血管生成因子,是RNase超家族中惟一具有促血管生成能力的成员,也是目前已知的所有血管生成因子中独具核糖核酸酶活性的因子。ANG具有3个功能元件,即RNase活性中心、细胞表面结合位点及核定位序列。ANG参与血管生成的各个阶段,是其他血管生成因子诱导新血管生成的枢纽,其作用受到受体调节。在肿瘤的发生、发展及恶化过程中,ANG也具有非常重要的作用。通过对ANG促血管生成及细胞增殖机制的研究,为治疗肿瘤提供了多种靶点和途径。 Angiogenin is a potent angiogenic factor, and it is the only member of RNase superfamliy found to be angiogenic. Angiogenin have three essensial functional elements： the fibonuleoytic active site, the cell-binding site and the nuclear location site. It is nearly involved in every step in angiogenesis and its inducing angiogenesis is regulated via receptor modulation. Angiogenin-stimulated rRNA transctiption in endothlial cells may serve as a crossroad in the process of angiogenesis induced by various angiogenic factor. Its angiogenic activity appears to be critical for mantenance and support of tumour growth.
作者 张雷雷 胥全彬 马清钧
机构地区 军事医学科学院微生物与流行病研究所
出处 《生物技术通讯》 CAS 2006年第2期248-251,共4页 Letters in Biotechnology
关键词 血管生成素 血管生成 核糖核酸酶 细胞表面结合位点 核定位序列 angiogenin angiogenesis RNase cell-binding site nuclear location site
分类号 R322.12 [医药卫生—人体解剖和组织胚胎学] Q26 [生物学—细胞生物学]
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参考文献29

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二级参考文献17

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  • 9Kao RY, Jenkins JL, Olson KA, Key ME, Fett JW, Shapiro R. A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity. Proc Natl Acad Sci USA, 2002, 99(15): 10066 -10071.
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生物技术通讯
2006年 第2期

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