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反义寡核苷酸诱导肝癌细胞对化疗药物的增敏作用

Chemosensitization of hepatocellular carcinoma using antisense oligonucleotides
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摘要 胰岛素样生长因子1型受体（IGF-1R）是一种跨膜酪氨酸蛋白激酶,它在多数肿瘤细胞中均有过量表达,形成并维持肿瘤细胞的转化表型,参与细胞的增殖和分化,与肿瘤细胞的浸润性生长和转移密切相关.有研究表明人肝癌细胞HepG2中IGF-1R呈现高表达.我们应用前期筛选出的、能够显著抑制IGF-1R表达的反义寡核苷酸（IGF1R-AS）,选择治疗肝癌的常用化疗药物顺铂（DDP）、5氟尿嘧啶（5 Fu）和阿霉素（ADM）分别与IGF-1R联用,分析其对人肝癌细胞HepG2增殖的抑制作用,以探讨联合治疗用于抗肝癌治疗的可能性.
作者 王芝艳 林汝仙 王升启
机构地区 军事医学科学院辐射与放射医学研究所
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2006年第4期242-242,246,共2页 Chinese Journal of Hepatology
关键词 癌 肝细胞 胰岛素样生长因子1 受体 反义寡核苷酸 Carcinoma, hepatocellular Insulin-like growth factor l Receptor, antisense oligonucleotide
分类号 R735.7 [医药卫生—肿瘤] R735.2 [医药卫生—肿瘤]
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中华肝脏病杂志
2006年 第4期

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