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表皮分化复合物和皮肤病 被引量：1

Epidermal Differentiation Complex and Skin Diseases
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摘要 表皮分化复合物基因是一呈簇状分布于染色体1q21上的基因家族,它与表皮的终末分化密切相关。这些蛋白表达在角质形成细胞的各层。它们的基因突变,mRNA表达量的改变,或是蛋白结构功能的变化,和多种角化异常的皮肤病及皮肤肿瘤有关。无论是基因水平的突变还是mRNA水平的变化,或是蛋白结构功能的改变都从一定程度上解释了疾病的发病机制。 The epidermal differentiation complex （ EDC ） encoded genes are a gene cluster located on human chromosome lq21. The EDC plays an important role in terminal differentiation of the human epidermis and is expressed in each layer of the epidermis. The gene mutation, variation of mRNA level and change of structure as well as function of EDC, are all associated with many cutaneous disorders of keratinization and skin tumors, which may explain the pathogenesis of these diseases to some extent.
作者 陈小英 郑捷
机构地区 上海交通大学医学院附属瑞金医院皮肤科
出处 《国际皮肤性病学杂志》 2006年第3期185-187,共3页 International Journal of Dermatology and Venereology
关键词 表皮分化复合物 皮肤疾病 Epidermal differentiation complex Skin disease
分类号 R751 [医药卫生—皮肤病学与性病学]
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参考文献22

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同被引文献12

  • 1徐薇,赵俊英,赵绘,顾菲,黄笑鸣.毛囊闭锁性三联征一例及家系分析[J].中华皮肤科杂志,2005,38(3):157-159. 被引量：11
  • 2王培光,林达,王红艳,李卉,高敏,周文明,刘盛秀,杨森,张学军.毛囊闭锁三联症一家系调查[J].临床皮肤科杂志,2006,35(1):42-43. 被引量：6
  • 3张学军.复杂疾病的遗传学研究策略[J].安徽医科大学学报,2007,42(3):237-240. 被引量：31
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  • 6Sellheyer K,Krahl D." Hidradenitis suppurativa" is acne inversa!An appeal to (finally) abandon a misnomer[J].Int J Dermatol,2005,44 (7):535-40.
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国际皮肤性病学杂志
2006年 第3期

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