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AMP-18,一种新发现的胃黏膜保护因子 被引量：6

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摘要 AMP-18是一种新发现的由胃腺体上皮细胞合成的小分子蛋白质,独特表达于胃黏膜,机体其他部位少见,胃癌组织中表达缺失．AMP-18 由185个氨基酸组成,除去N端信号肽(20个氨基酸)后大小约18 ku,第54-150个氨基酸组成高度保守的结构域(BRICHOS区域)承担主要的生理功能．AMP-18由胃腺体上皮细胞以胞吐的方式分泌到胃黏液中,他的合成和分泌与个体生长发育有关,并受福斯高林、吲哚美辛、地塞米松等药物的影响．目前发现 AMP-18的生理功能主要有促进胃黏膜上皮细胞的有丝分裂,促进细胞的迁徙,促胃肠黏膜损伤的修复,保持胃肠黏膜的完整等．
作者 陈美娅 任建林 潘金水
机构地区 厦门大学附属中山医院消化内科厦门市消化疾病研究所
出处 《世界华人消化杂志》 CAS 北大核心 2006年第8期805-809,共5页 World Chinese Journal of Digestology
关键词 AMP-18 胃黏膜保护 细胞有丝分裂 细胞 迁徙
分类号 R573 [医药卫生—消化系统]
  • 相关文献

参考文献31

  • 1任建林,卢雅丕,潘金水.胃黏膜保护的基础与临床研究进展[J].世界华人消化杂志,2005,13(21):2521-2529. 被引量：17
  • 2Bi LC, Kaunitz JD. Gastroduodenal mucosal defense: an integrated protective response. Curr Opin Gastroenterol 2003; 19: 526-532
  • 3Tsukimi Y, Okabe S. Recent advances in gastrointes-tinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing. Biol Pharm Bull 2001; 24: 1-9
  • 4Powell CT. Characterization of a Novel Messenger RNA and Immunochemical Detection of its Protein From Porcine Gastric Mucosa (PhD dissertation). Chicago IUoCP, 1987
  • 5Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. Am J Physiol Gastrointest Liver Physiol 2003; 285: G332-G343
  • 6Oien KA, McGregor F, Butler S, Ferrier RK, Downie I, Bryce S, Burns S, Keith WN. Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation. J Pathol 2004; 203: 789-797
  • 7Sanchez-Pulido L, Devos D, Valencia A. BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem Sci 2002; 27: 329-332
  • 8Toback FG, Walsh-Reitz MM, Musch MW, Chang EB, Del Valle J, Ren H, Huang E, Martin TE. Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am J Physiol Gastrointest Liver Physiol 2003; 285: G344-G353
  • 9Petri MK, Lee PC. Effects of dexamethasone on antral mucosal protein and gastric development in postnatal rats. J Pediatr Gastroenterol Nutr 2005; 40: 461-466
  • 10Lee ER. Dynamic histology of the antral epithelium in the mouse stomach: III. Ultrastructure and rene-wal of pit cells. Am J Anat 1985; 172: 225-240

二级参考文献11

共引文献16

同被引文献25

  • 1吕岩红,李玉兰,董国刚,吴燕,李晓冬,宋燕妮.多因素诱导构建大鼠胃癌模型[J].哈尔滨医科大学学报,2005,39(3):226-227. 被引量：6
  • 2Ling Yang.Incidence and mortality of gastric cancer in China[J].World Journal of Gastroenterology,2006,12(1):17-20. 被引量：347
  • 3Shu-Qing Shi,Jian-Ting Cai,Jian-Ming Yang.Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer[J].World Journal of Gastroenterology,2006,12(19):3119-3122. 被引量：14
  • 4Oien K A, McGregor F, Butler S, et al. Gastrokine-1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation [ J ]. J Pathol, 2004,203 ( 3 ) : 789 - 797.
  • 5Powell C T. Characterization of a novel messenger RNA and immunochemical detection of its protein from porcine gastric mucosa(Phi) dissertation) [ 1)]. Chicago : IUoCP, 1987.
  • 6Martin T E,Powell C T, Wang Z, et al. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa[J]. Am J Physiol Gastrointest Liver Physiol, 2003, 285(2) :G332 - G343.
  • 7Toback F G, Walsh-Reitz M M, Musch M W, et al. Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic [ J ]. Am J Physiol Gastrointest Liver Physio1,2003,285 (2) : G344 - G353.
  • 8Walsh-Reitz M M, Huang E F, Musch MW, et al. AMP-18 protects barrier function of colonic epithelial cells:role of tight junction proteins [ J ]. Am J Physiol Gastrointest Liver Physiol, 2005,289( 1 ) : G163 - G171 .
  • 9Yoshikawa Y, Mukai H, Hino F, et al. Isolation of two novel genes, down-regulated in gastric cancer [J]. Jpn J Cancer Res ,2000,91 (5) :459 - 463.
  • 10He Q Y, Cheung Y H, Leung S Y, et al. Diverse proteomic alterations in gastric adenocarcinoma [ J ]. Proteomics, 2004, 4 (10) :3276 - 3287.

引证文献6

二级引证文献11

世界华人消化杂志
2006年 第8期

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