摘要
AIM： To further assess of the incidence and localization of Crohn＇s disease （CD） in a well-defined population during the 1990s and to evaluate the prevalence of CD on the 1^st of January 2002. METHODS： In a retrospective population based study, all 16-90 years old citizens of Stockholm County diagnosed as having CD according to Lennard Jones＇ criteria between 1990 and 2001 were included. Case identification was made by using computerized inpatient and outpatient registers. Moreover private gastroenterologists were asked for possible cases. The extent of the disease and the frequency of anorectal fistulae were determined as were the ages at diagnosis. Further, the prevalence of CD on the 1^st of January 2002 was assessed. RESULTS： All the 1 389 patients, 689 men and 700 women, fulfilled the criteria for CD. The mean incidence rate for the whole period was 8.3 per 10s （95%CI 7.9 -8.8）. There was no difference between the genders. The mean annual incidence of the whole study period for colorectal disease and ileocecal disease, was 4.4 （95%CI 4.0-4.7） and 2.4 （95%CI 2.1-2.6） per 10s, respectively. Perianal disease occurred in 13.7% （95%CI 11.9-15.7 %） of the patients. The prevalence of CD was 213 per 100 000 inhabitants. CONCLUSION： The incidence of CD has markedly increased during the last decade in Stockholm County and 0.2% of the population suffers from CD. The increase is attributed to a further increase of colorectal disease, while the incidence of ileocecal disease has remained stable.
瞄准：进一步在 1990 年代期间在一张明确的人口 Crohn 的疾病(CD ) 的发生和本地化估计并且在 2002 年 1 月 1 日评估 CD 的流行。方法：在基于的一张回顾的人口学习，作为根据 Lennard Jone 在 1990 和 2001 之间的标准有 CD 诊断的斯德哥尔摩县的所有 16-90 岁公民被包括。盒子鉴定被使用计算机化的住院病人和门诊病人寄存器做。而且私人胃的肠学被要求可能的盒子。疾病的程度和肛门直肠的 fistulae 的频率是被决定是在诊断的年龄。进一步， CD 在上的流行(st ) 1 2002 年 1 月被估计。结果：所有 1 389 个病人， 689 个男人和 700 个女人，为 CD 完成了标准。为整个经期的吝啬的发生率每 10 是 8.3 (5 )(95%CI 7.9 -8.8) 。性之间没有差别。为颜色的整个学习经期的吝啬的年度发生表面的疾病和回盲肠疾病，是 4.4 (95%CI 4.0-4.7 ) 并且 2.4 (95%CI 2.1-2.6 ) 每 10 (5 ) 分别地。肛周疾病发生在 13.7%(95%CI 11.9-15.7 %) 病人。CD 的流行每 100,000 个居民是 213。结论：CD 的发生显著地在斯德哥尔摩县在最后十年期间增加了， 0.2% 人口受不了 CD。增加被归因于颜色的另外的增加表面的疾病，当回盲肠疾病的发生仍然保持稳定时。
基金
Supported by the grants from Knut and Alice Wallenbergs foundation
