摘要
[目的]探讨酒精性晚期股骨头坏死与长期、过量饮酒的关系。[方法]回顾本院165例人工全髋关节置换病例。分析其中27例酒精性晚期股骨头坏死的临床资料,结合文献复习,探讨酒精性股骨头坏死的发病机理。长期大量饮酒与股骨头缺血性坏死、血液生化学和凝血功能等之间的关系。比较文献报道的实验结果有何异同。[结果]大量长期饮酒可导致股骨头坏死,是多方面因素综合的结果;日均饮酒750 m l以上者,有发生晚期双侧或单侧股骨头坏死的危险;血液生化观察指标无明显改变,但与凝血功能降低有关;股骨头坏死与髋关节的骨性关节炎可同时发生。[结论]长期大量饮酒,日均饮酒量大于750 m l以上者,有导致股骨头坏死的可能;血液生化的改变无特异性的意义;坏死的严重程度与酒量多少、时间长短有关;酒精性股骨头缺血性坏死的晚期患者,行人工全髋关节置换应是最佳选择,但这类患者术中术后有渗血较多的倾向。
[ Objective] To discuss the relation-ship between AAONFH （ advanced alcoholic osteonecrosis of femoral head） and extended overdose drinking. [ Method] Reviewed 165 cases of total hip arthroplasty, to analyzed the clinical data among 27 AAONFH cases, reviewed the literatures, discussed the pathogenesis of AAONFH and the relation-ship between blood biochemistry and blood cloting funtion and compared the experimental results among literatures. [ Result] There＇s various factors resulted in osteonecrosis of the femoral head associated with alcohol long-term over intake. Individuals consuming more than 750 ml of alcohol daily were at greater risk of double or half ONFH, There＇s no change in biochemical test, but blood clot- ting funtion in this case would degrade, osteoarthritis of hip would synchronize. [Condusion ] Individuals consuming more than 750 ml of alcohol daily have the potentiality of ONFH ; It＇s no specificity significance in biochemical test, the necrosis extent of the femoral head is relative to the capacity and times of alcohol intake. THR （ total hip replacement） is the best treatment for AAONFH, but there＇s more staxis potentiality in this cases.
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2006年第9期669-671,共3页
Orthopedic Journal of China
关键词
酒精性
晚期
股骨头坏死
Alcoholic
Advanced
Osteonecrosis of the femoral head （ONFH）
