摘要
高等生物的一个重要代谢调控机制是通过对酶的磷酸化和去磷酸化来进行的,哺乳动物的丙酮酸脱氢酶复合体(pyruvate dehydrogenase complex,PDHc)也是如此。PDHc的活性的调节主要是通过对其E1(pyru-vate dehydrogenase,PDH)的磷酸化和去磷酸化来实现的。当机体主要靠储存的脂肪生存而所存的葡萄糖仅供大脑和神经组织等只能依靠葡萄糖来提供能量的器官使用的时候,即葡萄糖缺乏时,就需要抑制PDHc的活性。主要探讨了哺乳动物在特定器官中和特定的一些生理条件下,PDHc活性改变的一些规律。
Through the phosphorylation and dephosphorylation of the El（pyruvate dehydrogenase, PDH） of the PDHc, the activity of the Mammalian pyruvate dehydrogenase complex has been reguqated. When the body should be living primarily off its stored fat and thereby conserve ingglucose for use by the brain, the rate of pyruvate decarboxylation has to be carefully contr-olled to match the overall energy need of the body. In this paper, Mechanisms have there-fore discussed to inactivate the pyruvate dehydrogenase complex when glucose becomes scarce.
出处
《生物技术通报》
CAS
CSCD
2006年第1期9-12,共4页
Biotechnology Bulletin
关键词
丙酮酸脱氢酶复合体
丙酮酸脱氢酶激酶
活性调节
磷酸化
去磷酸化
Pyruvate dehydrogenase complex Pyruvate dehydrogenase kinase Regulation of the activity Phosphorylation Dephosphorylation
