摘要
目的:探讨白细胞介素-6(IL-6)在绝经后女性原发性干燥综合征(primarySj<gren’ssyndrome,pSS)中的作用。方法:应用酶联免疫吸附试验(ELISA)测定21例绝经后pSS患者(患者组)和21例绝经后健康女性(对照组)血清及唾液中IL-6水平,并依本院常规方法检测患者血清IgG、IgA、IgM和血沉(ESR)。结果:患者组血清及唾液IL-6水平高于对照组(P<0.01)。患者组血清及唾液IL-6水平与血清IgG、ESR水平呈直线正相关(r分别为0.699,0.757和0.546,0.544,t分别为4.261,5.050和2.841,2.826,P<0.01或P<0.05),与血清IgA、IgM水平无直线关系(r分别为0.392,0.412和0.393,0.291,t分别为1.857,1.971和1.863,1.326,P>0.05)。患者组血清IL-6与唾液IL-6水平呈直线正相关(r=0.649,t=3.718,P<0.01)。结论:IL-6可能主要通过诱导IgG的合成和分泌参与pSS的发病及进展,唾液IL-6水平可反映血清IL-6水平,用于评估病情活动性。
Objective： To investigate the role of interleukin-6 （IL-6） in the pathogenesis of primary Sjoegren＇s syndrome （pSS）. Methods： Serum and saliva specimen of twenty-one postmenopausal patients with laSS （the laSS group） and twenty-one postmenopausal healthy women（the control group） were collected. Enzyme linked immunosorbent assay （ELISA） were used to determine levels of IL-6 then IgG, IgA, IgM and ESR were measured by routine methods in our hospital. Results： The serum and saliva level of IL-6 in pSS patients were higher than that in the control group （P 〈 0.01）. The serum and saliva level of IL- 6 in the pSS group had linear positive correlation with IgG and ESR in serum （r=0.699, 0.757 and 0.546,0.544 t=4.261, 5.050 and 2.841,and 2.826 respectively, P 〈 0.01 or P 〈 0.05, but had no linear correlation with IgA and IgM in serum （r=0.392, 0.412 and 0.393, 0.291, t=1.857, 1.971 and 1.863,1.326 respectively, P〉 0.05）. The serum and saliva level of IL-6 in pSS patients had linear （r=0.649, t=3.718, P 〈 0.01）. Conclusion： IL-6 is an important factor on the pathogenesis and perpetuation of pSS by inducing IgG synthesis and secretion. The IL-6 level in saliva which may be a indicator of that in serum can be used to evaluate the activity of pSS.
出处
《天津医药》
CAS
北大核心
2006年第4期236-237,共2页
Tianjin Medical Journal
