期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

新生血管性眼病的基因治疗现状 被引量：2

原文传递
导出
摘要 　　新生血管形成的基本过程包括血管内皮细胞（EC）激活、细胞外基质（ECM）降解、EC移行和增殖、管腔结构形成以及血管外膜形成.在新生血管的形成过程中,血管生成诱导因子和血管生成抑制因子共同作用,两者的平衡控制了血管的形成[1].如果这种平衡被改变,减少血管生成抑制因子或增加血管生成诱导因子的水平,都将促进新生血管的形成.很多细胞因子、细胞及ECM参与了新生血管的形成过程。
作者 张新秀 何守志
机构地区 解放军总医院眼科
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2006年第4期312-314,共3页 Chinese Journal of Geriatrics
关键词 新生血管性眼病 细胞外基质(ECM) 血管生成抑制因子 治疗现状 血管内皮细胞 基因 新生血管形成 诱导因子 多细胞因子 基本过程
分类号 R771.3 [医药卫生—眼科]
  • 相关文献

参考文献23

  • 1Hanahan D,Folkman J.Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.Cell,1996,86:353-364.
  • 2Ambati J,Ambati BK,Yoo SH,et al.Age-related macular degeneration:etiology,pathogensis,and therapeutic strategies.Surv Ophthalmol,2003,48:257-293.
  • 3Dawson DW,Volpert OV,Gillis P,et al.Pigment epithelium-derived factor:a potent inhabitor of angiogenesis.Science,1999,285:245-248.
  • 4Renno RZ,Youssri AI,Mchaud N,et al.Expression of pigment epithelium-derived factor in experimental choroidal neovascularization.Invest Ophthalmol Vis Sci,2002,43:1574-1580.
  • 5Holekamp NM,Bouck N,Volpert O,et al.Pigment epithelium-derived factor is deficient in the vitreous of patients with-choroidal neovascularization due to age -related macular degeneration.Am J Ophthalmol,2002,134:220-227.
  • 6O' Reilly MS,Holmgren L,Shing Yuen,et al.Angiostatin:A novel angiogenesis inhibitor that mediated the suppression of metastases by a lewis lung carcinoma.Cell,1994,79:315-328.
  • 7Kim YM,Hwang S,Kim YM,et al.Endostatin blocks vascular endothelial growth factor mediated signaling via direct interaction with KDR/Flk1.J Biol Chem,2002,277:27872-27879.
  • 8Goldman CK,Kendall RL,G.Cabrer,et al.Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth,metastasis,and mortality rate.Proc Natl Acad Sci U S A,1998,95:8795-800.
  • 9Steen B,Sejersen S,Berglin L,et al.Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes.Invest Ophthalmol Vis Sci,1998,39:2194-2200.
  • 10Lai CM,Spilsbury K,Brankov M,et al.Inhabition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA.Exp Eye Res,2002,75:625-634.

二级参考文献10

  • 1樊莹,许迅,王丰,张皙,黄倩.反义RNA抑制人视网膜色素上皮细胞VEGF分泌的研究[J].眼科研究,2003,21(3):254-257. 被引量：2
  • 2Robinson GS, Pierce EA, Rook SL, et al. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy [J]. Proc Natl Acad Sci USA, 1996, 93: 4851 - 4856
  • 3Meneses PI,Hajjar KA, Berns KI,et al. Recombinant angiostatin prevents retinal neovascularization in a murine proliferative retinopathy model[ J].Gene Therapy ,2001,8 ( 8 ): 646 - 648
  • 4Penn JS, Rajaratnam VS, Collier R J, et al. The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity [J]. Invest Ophthalmol Vis Sci ,2001,42 ( 1 ): 283 - 290
  • 5Sone H,Kawikami Y, Segawa T, et al. Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy [ J ]. Life Sci,1999,65 ( 24 ): 2573 - 2580
  • 6Yoshida A, Yoshida S, Ishibashi T, et al. Suppression of retinal neovascularization by NF-kappeB inhibitor pyrrolidine dithiocarbamate in mice[J]. Invest Ophthalmol Vis Sci,1999, 40(7): 1624 - 1629
  • 7Hasuka H, Thomson LR, Dorey CK. Pentoxifylline inhibition of vasculogenesis in the neonatal rat retinal[J].Invest Ophthalmol Vis Sci,2000,41 (9): 2774 - 2778
  • 8Shafiee A,Penn JS,Krutzsch HC,et al. Inhibition of retinal angiogenesis by peptides derived from thrombospondin-1 [ J ]. Invest Ophthalmol Vis Sci,2000, 41 ( 8 ): 2378 - 2388
  • 9Mustonan T, Alitalo K. Endothelial receptor tyrosine kinases involved in angiogenesis[J].J Cell Biol, 1995,129 ( 4 ): 895 - 898
  • 10王丰,夏欣,胡宏惠,李凌,田毓华,陈霞芳,黄倩.脂质体介导质粒DNA转移至视网膜的观察[J].中华眼科杂志,2002,38(9):520-522. 被引量：5

共引文献5

同被引文献64

引证文献2

二级引证文献7

中华老年医学杂志
2006年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部