摘要
目的：探讨p53在肾母细胞瘤中的表达及其SCT征象的关系。方法：用免疫组化ABC法检测p53蛋白在28例肾母细胞瘤标本中的表达，并回顾分析28例经手术、病理证实为肾母细胞瘤的SCT表现。结果：28例肾母细胞瘤中p53阳性表达7例，阳性率为25％；在Ⅰ～Ⅱ期和Ⅲ～Ⅳ期之间（P=0．005）以及不同的淋巴结转移之间（P=0．043）p53的阳性表达具有显著性；SCT和病理结果之间有很好的一致性（P=0．004），说明SCT的诊断结果是可信的；在SCT淋巴结转移阳性组及阴性组，p53的阳性表达率分别为62．5％（5／8）和10．0％（2／20），两组比较．差异具有显著性（P=0．009）。结论：应用SCT结合p53的检测有助于评价肾母细胞瘤的临床病理特征、预后以及确立个体化的治疗方案，可在一定程度上从蛋白水平认识肾母细胞瘤的生物学特性的外在表现。
Objective：To investigate the expression of p53 in nephroblastoma and the relationship between it and the sign of spiral CT. Methods：Immunohistochemical technique was used to detect the expression of p53 in 28 cases of nephroblastoma,and the CT manifestations in 28 cases of nephroblastoma proved by operatively and pathologically were studied retrospectively. Results：The number of positive expression of p53 was 7 among 28 cases of nephroblastoma,and the positive rate was 25% ; The positive expression of p53 between Ⅰ～Ⅱ stage and Ⅲ～Ⅳ stage（P=0. 005） or different lymph nodes state （P=0. 043） showed significant ;The good ponsistency （P=0. 004）between SCT and pathology indicated the diagnostic results of SCT were credible;The positive rate of p53 in the lymph node metastasis group was 62. 5% （5/8）,and in the no metastasis group was 10.0%（2/20）,and the difference between them was significant （P= 0. 009）, Conclusions：The combination of SCT with p53 helps to evaluate the clinic-pathologic character of nephroblastoma ,its prognosis and makes individual therapy,in the same time,the outside manifestations of the biological character of nephroblastoma can be studied from protein level.
出处
《中国误诊学杂志》
CAS
2006年第8期1422-1424,共3页
Chinese Journal of Misdiagnostics
