摘要
用ＩＣＳ－Ⅱ免疫化学系统（Ｂｅｃｋｍａｎ）检测１８２例慢性浅表性胃炎、慢性萎缩性胃炎，十二指肠球部溃疡和胃癌患者的胃液发现，胃液中含数量不等的Ｃ反应蛋白（ＣＲＰ）、α１抗胰蛋白酶（α１ＡＴ）、α１酸性糖蛋白（α１ＡＧ）、Ｃ３和Ｃ４等急性时相血浆蛋白（ＡＰＰｓ），证明这些蛋白向胃腔内分泌－腔分泌。慢性萎缩性胃炎较浅表性胃炎或兼有十二指肠球部溃疡者显著升高（Ｐ＜０．０１），胃癌又较慢性萎缩性胃炎显著升高（Ｐ＜０．０１），胃癌术后ＡＰＰｓ明显下降（Ｐ＜０．０１）。这不仅说明ＡＰＰ可能参与疾病的发生和发展，对这些疾病的鉴别也有一定价值。胃癌患者用肿瘤坏死因子治疗后，可刺激Ⅰ型ＡＰＰ表达，使ＣＲＰ、α１ＡＧ和Ｃ３和Ｃ４显著升高（Ｐ＜０．０５），但对Ⅱ型ＡＰＰ却有抑制作用，导致α１ＡＴ下降（Ｐ＜０．０５）。这对治疗有一定指导意义。
The gastric juice of 182 cases patients with chronic surface gastritis(CSG),chronic atrophic gastritis(CAG),duodenal ulcer (DUA),and carcinoma of stomach were assay by Immunochemical System-Ⅱ (Beckman). The results showed that the gastric juice contain C-reactive protein, α_1-antitrypsin, α_1-acid glycoprotein , C_3 and C_4, etc. and demonstrated that the release of acute plasma proteins (APP_s) into the antral lumen-cavity secrete. The APP_s of patients with CAG were significantly higher as compared with CSG or CSG/DUA (P<0. 01) and that with Ca were significantly higher as compared with CAG(P<0. 01). After operation, the APP_s of patients with carcinoma of stomach were significantly lower as compared with before. These results sugested that the APP_s not only participate in the formation and advance of gastropathy ,but also help differential diagnosis of CSG ,CAG or Ca. After treatment with tumor necrosis factor (TNF), stimulation of type-1 APP_s and inhibition type-2 APP_s, so that CRP,α1-AG,C_3 and C_4 of patients with carcinoma of stomach were significantly higher and α1-AT were significantly lower as compared with before treatment.
出处
《胃肠病学和肝病学杂志》
CAS
1996年第1期42-44,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
时相血浆蛋白
肿瘤坏死因子
胃肿瘤
胃疾病
carcinoma of stomach gastritis acute phase plasma proteins (APP_s)gastric juice tumor necrosis factor(TNF)
