摘要
目的研究Survivin基因在非霍奇金淋巴瘤组织中的表达以及临床意义。方法应用免疫组化法检测38例非霍奇金淋巴瘤及18例反应性淋巴结炎组织中Survivin蛋白质的表达。结果38例非霍奇金淋巴瘤组织中Survivin阳性检出率为94.7%,18例反应性淋巴结炎组织中Survivin蛋白质呈阴性表达。在Survivin表达阳性的非霍奇金淋巴瘤患者中,侵袭性组阳性细胞百分数高于惰性组(P<0.05),其与年龄、发生部位、临床分期、全身症状、免疫表型及血清LDH水平等均无明显的关系(P值均>0.05)。结论Survivin的表达与非霍奇金淋巴瘤的侵袭程度相关,Survivin表达越高,侵袭程度也越高,预后越差。
Objective To investigate the expression of Survivin in the tissues of non-Hodgkin lymphoma and it chnical significance. Methods We examined the expression of Survivin in 38 cases of non-Hodgkin lymphoma and 18cases of reactive lymphoditis by immunohistochemical method. Results There were the positive expression of Survivin protein in 36 of 38 cases （94.7%）, while none of 18 patients with reactive lymphoditis was positive. Among the positive expression of patients, the positive expression percentage of survivin protein in the cells of NHLwas higher in the aggressive group than that in the indolent group（P〈0.05）. The expression level of Survivin protein was no difference to them including age, location of the disease, ehnieal stage, immunophenotype and serum lactate dehydrogenase（P〉0.05）.Conclusion The expression level of survivin in non-Hedgkin lymphoma is correlated with aggressive degree. The more expression level of survivin, the higher aggressive degree of NHL.
出处
《基层医学论坛》
2006年第5期395-396,共2页
The Medical Forum
